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ENZYME

ENZYME entry: EC 1.2.1.27

Accepted Name
methylmalonate-semialdehyde dehydrogenase (CoA acylating)
Alternative Name(s)
methylmalonate-semialdehyde dehydrogenase (acylating)
MMSA dehydrogenase
MSDH
Reaction catalysed
2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA
Comment(s)
  • Also converts 3-oxopropanoate into acetyl-CoA.
  • The reaction occurs in two steps with the decarboxylation process preceding CoA-binding.
  • Bicarbonate rather than CO2 is released as a final product.
Cross-references
BRENDA 1.2.1.27
EC2PDB 1.2.1.27
ExplorEnz 1.2.1.27
PRIAM enzyme-specific profiles 1.2.1.27
KEGG Ligand Database for Enzyme Nomenclature 1.2.1.27
IUBMB Enzyme Nomenclature 1.2.1.27
IntEnz 1.2.1.27
MEDLINE Find literature relating to 1.2.1.27
MetaCyc 1.2.1.27
Rhea expert-curated reactions 1.2.1.27
UniProtKB/Swiss-Prot
Q9I702, BAUC_PSEAE A0RDW1, IOLA1_BACAH Q81QR5, IOLA1_BACAN
Q63BL0, IOLA1_BACCZ Q6HJ19, IOLA1_BACHK Q65IX1, IOLA1_BACLD
A9VF06, IOLA1_BACMK Q5L025, IOLA1_GEOKA A4IPB2, IOLA1_GEOTN
Q8ES27, IOLA1_OCEIH Q5WKZ1, IOLA1_SHOC1 A0REB5, IOLA2_BACAH
Q81QB6, IOLA2_BACAN Q63B74, IOLA2_BACCZ Q6HIK3, IOLA2_BACHK
Q65D00, IOLA2_BACLD A9VMS6, IOLA2_BACMK Q5KYR4, IOLA2_GEOKA
A4IPF5, IOLA2_GEOTN Q8EMV4, IOLA2_OCEIH Q5WH11, IOLA2_SHOC1
Q4V1F6, IOLA3_BACCZ Q5KYK0, IOLA3_GEOKA Q738L2, IOLA_BACC1
B7IW48, IOLA_BACC2 B7H597, IOLA_BACC4 B7HR31, IOLA_BACC7
A7GPH3, IOLA_BACCN B9IZZ7, IOLA_BACCQ Q81DR5, IOLA_BACCR
A7BJC4, IOLA_BACNA A8FDV4, IOLA_BACP2 P42412, IOLA_BACSU
A7ZAI1, IOLA_BACVZ Q9KAH5, IOLA_HALH5 A5YBJ3, IOLA_LACCA
Q92EQ7, IOLA_LISIN C1KZ99, IOLA_LISMC Q723T1, IOLA_LISMF
B8DCT8, IOLA_LISMH Q8Y9Y4, IOLA_LISMO Q17M80, MMSA_AEDAE
Q7QC84, MMSA_ANOGA Q0WM29, MMSA_ARATH Q07536, MMSA_BOVIN
P52713, MMSA_CAEEL Q54I10, MMSA_DICDI Q7KW39, MMSA_DROME
Q29HB2, MMSA_DROPS Q02252, MMSA_HUMAN Q9EQ20, MMSA_MOUSE
P28810, MMSA_PSEAE Q02253, MMSA_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
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