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ENZYME

ENZYME entry: EC 1.2.1.88

Accepted Name
L-glutamate gamma-semialdehyde dehydrogenase
Alternative Name(s)
1-pyrroline-5-carboxylate dehydrogenase
Delta(1)-pyrroline-5-carboxylate dehydrogenase
pyrroline-5-carboxylate dehydrogenase
Reaction catalysed
H2O + L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + L-glutamate + NADH
Comment(s)
  • This enzyme catalyzes the irreversible oxidation of glutamate-gamma- semialdehyde to glutamate as part of the proline degradation pathway.
  • (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde.
  • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
  • The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1- pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)- 1-pyrroline-5-carboxylate is converted into D-glutamate.
  • NADP(+) can also act as acceptor, but with lower activity.
  • Formerly EC 1.5.1.12.
Cross-references
BRENDA 1.2.1.88
EC2PDB 1.2.1.88
ExplorEnz 1.2.1.88
PRIAM enzyme-specific profiles 1.2.1.88
KEGG Ligand Database for Enzyme Nomenclature 1.2.1.88
IUBMB Enzyme Nomenclature 1.2.1.88
IntEnz 1.2.1.88
MEDLINE Find literature relating to 1.2.1.88
MetaCyc 1.2.1.88
Rhea expert-curated reactions 1.2.1.88
UniProtKB/Swiss-Prot
Q8VZC3, AL121_ARATH A7YWE4, AL4A1_BOVIN Q7SY23, AL4A1_DANRE
Q54RA2, AL4A1_DICDI P30038, AL4A1_HUMAN Q8CHT0, AL4A1_MOUSE
P0C2X9, AL4A1_RAT P78568, PUT2_AGABI Q9P8I0, PUT2_EMENI
O74766, PUT2_SCHPO P07275, PUT2_YEAST P09546, PUTA_ECOLI
O52485, PUTA_KLEAE P23725, PUTA_KLEPN P95629, PUTA_RHIML
P10503, PUTA_SALTY Q9K9B2, ROCA1_HALH5 P94391, ROCA2_BACSU
Q9K5Z5, ROCA2_HALH5 B7GFV3, ROCA_ANOFW C3PBP4, ROCA_BACAA
C3L546, ROCA_BACAC A0R909, ROCA_BACAH Q81ZF8, ROCA_BACAN
B7JM99, ROCA_BACC0 P62028, ROCA_BACC1 B7IUW8, ROCA_BACC2
C1EV77, ROCA_BACC3 B7H4V1, ROCA_BACC4 B7HSW8, ROCA_BACC7
A7GKJ4, ROCA_BACCN B9J1L9, ROCA_BACCQ Q81IP0, ROCA_BACCR
Q63GS0, ROCA_BACCZ Q6HP91, ROCA_BACHK Q65NN2, ROCA_BACLD
A9VRG6, ROCA_BACMK A8F9T1, ROCA_BACP2 P39634, ROCA_BACSU
Q5L3K8, ROCA_GEOKA C5D4J5, ROCA_GEOSW A4IJP9, ROCA_GEOTN
Q8ERF4, ROCA_OCEIH A7X6R7, ROCA_STAA1 A6U4T5, ROCA_STAA2
Q2FDV3, ROCA_STAA3 Q2FV67, ROCA_STAA8 A5IVY0, ROCA_STAA9
Q2YWA6, ROCA_STAAB Q5HCZ6, ROCA_STAAC A6QK44, ROCA_STAAE
P63939, ROCA_STAAM P99076, ROCA_STAAN Q6GDP4, ROCA_STAAR
Q6G6C0, ROCA_STAAS A8Z3F5, ROCA_STAAT Q8NUR2, ROCA_STAAW
Q5HL59, ROCA_STAEQ Q8CN04, ROCA_STAES Q4L966, ROCA_STAHJ
Q4A0E7, ROCA_STAS1

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