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ENZYME

ENZYME entry: EC 1.2.3.1

Accepted Name
aldehyde oxidase
Alternative Name(s)
quinoline oxidase
retinal oxidase
Reaction catalysed
an aldehyde + H2O + O2 <=> a carboxylate + H(+) + H2O2
Comment(s)
  • The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides.
  • The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11).
  • Formerly EC 1.2.3.11.
Cross-references
BRENDA 1.2.3.1
EC2PDB 1.2.3.1
ExplorEnz 1.2.3.1
PRIAM enzyme-specific profiles 1.2.3.1
KEGG Ligand Database for Enzyme Nomenclature 1.2.3.1
IUBMB Enzyme Nomenclature 1.2.3.1
IntEnz 1.2.3.1
MEDLINE Find literature relating to 1.2.3.1
MetaCyc 1.2.3.1
Rhea expert-curated reactions 1.2.3.1
UniProtKB/Swiss-Prot
Q7XH05, ALDO1_ORYSJ Q852M1, ALDO2_ORYSJ Q852M2, ALDO3_ORYSJ
Q7G191, ALDO4_ARATH Q69R21, ALDO4_ORYSJ P48034, AOXA_BOVIN
H9TB17, AOXA_CAVPO Q06278, AOXA_HUMAN Q5FB27, AOXA_MACFA
O54754, AOXA_MOUSE P80456, AOXA_RABIT Q9Z0U5, AOXA_RAT
H9TB19, AOXB_CAVPO C4NYZ3, AOXB_MACFA Q5SGK3, AOXB_MOUSE
Q5QE78, AOXB_RAT G3X982, AOXC_MOUSE Q5QE80, AOXC_RAT
H9TB18, AOXD_CAVPO Q3TYQ9, AOXD_MOUSE Q5QE79, AOXD_RAT
Q960A1, GAD3_CAEEL Q9FYG4, GLOX1_ARATH A0A2H4HHY6, GLOX_ARTAN
Q3HRQ2, GLOX_VITPS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.3.-
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