Expasy logo

ENZYME

ENZYME entry: EC 1.2.4.2

Accepted Name
oxoglutarate dehydrogenase (succinyl-transferring)
Alternative Name(s)
2-ketoglutarate dehydrogenase
2-oxoglutarate dehydrogenase
AKGDH
alpha-ketoglutarate dehydrogenase
alpha-ketoglutaric acid dehydrogenase
alpha-ketoglutaric dehydrogenase
alpha-oxoglutarate dehydrogenase
ketoglutaric dehydrogenase
OGDC
oxoglutarate dehydrogenase
oxoglutarate dehydrogenase (lipoamide)
Reaction catalysed
2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] <=> CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]
Comment(s)
  • It is a component of EC 1.2.1.105 in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.
  • It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
Cross-references
BRENDA 1.2.4.2
EC2PDB 1.2.4.2
ExplorEnz 1.2.4.2
PRIAM enzyme-specific profiles 1.2.4.2
KEGG Ligand Database for Enzyme Nomenclature 1.2.4.2
IUBMB Enzyme Nomenclature 1.2.4.2
IntEnz 1.2.4.2
MEDLINE Find literature relating to 1.2.4.2
MetaCyc 1.2.4.2
Rhea expert-curated reactions 1.2.4.2
UniProtKB/Swiss-Prot
Q23629, DHTK1_CAEEL Q54VG0, DHTK1_DICDI Q9VA02, DHTK1_DROME
Q7U0A6, KGD_MYCBO A1KI36, KGD_MYCBP Q9CC97, KGD_MYCLE
Q73WX4, KGD_MYCPA A0R2B1, KGD_MYCS2 A3Q3N5, KGD_MYCSJ
A1UK81, KGD_MYCSK Q1B4V6, KGD_MYCSS A5U1U6, KGD_MYCTA
P9WIS4, KGD_MYCTO P9WIS5, KGD_MYCTU A0PVU7, KGD_MYCUA
A1TDK2, KGD_MYCVP Q8NRC3, ODO12_CORGL P20707, ODO1_AZOVI
C3P487, ODO1_BACAA C3LAU3, ODO1_BACAC Q81TK1, ODO1_BACAN
B7JEU9, ODO1_BACC0 Q73BN8, ODO1_BACC1 B7IM94, ODO1_BACC2
C1ELG5, ODO1_BACC3 B7HH19, ODO1_BACC4 B7I0H2, ODO1_BACC7
A7GMD4, ODO1_BACCN B9IU58, ODO1_BACCQ Q81GF2, ODO1_BACCR
Q63EB1, ODO1_BACCZ Q6HLS8, ODO1_BACHK Q65IH4, ODO1_BACLD
A9VJX9, ODO1_BACMK A8FE66, ODO1_BACP2 P23129, ODO1_BACSU
A7Z5J9, ODO1_BACVZ Q148N0, ODO1_BOVIN B2S877, ODO1_BRUA1
Q2YLS2, ODO1_BRUA2 A6WXF0, ODO1_BRUA4 Q57AX5, ODO1_BRUAB
A9M8Q9, ODO1_BRUC2 C0RFG8, ODO1_BRUMB Q8YJE4, ODO1_BRUME
A5VSQ0, ODO1_BRUO2 B0CIS7, ODO1_BRUSI Q8FYF7, ODO1_BRUSU
P57388, ODO1_BUCAI Q8K9N3, ODO1_BUCAP Q89AJ7, ODO1_BUCBP
Q623T0, ODO1_CAEBR O61199, ODO1_CAEEL P51056, ODO1_COXBU
Q59106, ODO1_CUPNH Q54JE4, ODO1_DICDI P0AFG5, ODO1_ECO57
P0AFG4, ODO1_ECOL6 P0AFG3, ODO1_ECOLI C4L3W2, ODO1_EXISA
Q5L172, ODO1_GEOKA C5D802, ODO1_GEOSW P45303, ODO1_HAEIN
Q9KAT1, ODO1_HALH5 Q02218, ODO1_HUMAN Q72PJ7, ODO1_LEPIC
Q8F6S7, ODO1_LEPIN Q60HE2, ODO1_MACFA P86231, ODO1_MESAU
Q60597, ODO1_MOUSE Q8CUL8, ODO1_OCEIH Q5RCB8, ODO1_PONAB
Q5XI78, ODO1_RAT Q1RHI4, ODO1_RICBR Q92J42, ODO1_RICCN
Q4UKI8, ODO1_RICFE Q9ZDY3, ODO1_RICPR Q68XI7, ODO1_RICTY
O74378, ODO1_SCHPO Q5WG56, ODO1_SHOC1 P81895, ODO1_SOLTU
A7X295, ODO1_STAA1 A6U1N4, ODO1_STAA2 Q2FH25, ODO1_STAA3
Q2FYM1, ODO1_STAA8 A5ISU5, ODO1_STAA9 Q2YY05, ODO1_STAAB
Q5HG06, ODO1_STAAC A6QGW6, ODO1_STAAE Q931R8, ODO1_STAAM
Q99U74, ODO1_STAAN Q6GGZ5, ODO1_STAAR Q6G9E8, ODO1_STAAS
A8Z3Z0, ODO1_STAAT P0C601, ODO1_STAAU Q8NWR6, ODO1_STAAW
Q5HPC6, ODO1_STAEQ Q8CP83, ODO1_STAES Q4L6C4, ODO1_STAHJ
Q49XM5, ODO1_STAS1 Q6P6Z8, ODO1_XENLA P20967, ODO1_YEAST
Q9ULD0, OGDHL_HUMAN Q5R9L8, OGDHL_PONAB D3ZQD3, OGDHL_RAT
Q68EW0, OGDHL_XENLA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-