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ENZYME

ENZYME entry: EC 1.2.7.7

Accepted Name
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
Alternative Name(s)
2-ketoisovalerate ferredoxin reductase
2-oxoisovalerate ferredoxin reductase
3-methyl-2-oxobutanoate synthase (ferredoxin)
branched-chain ketoacid ferredoxin reductase
branched-chain oxo acid ferredoxin reductase
ketoisovalerate ferredoxin reductase
ketoisovalerate oxidoreductase
keto-valine-ferredoxin oxidoreductase
VOR
Reaction catalysed
3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters.
  • Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- pentanoate, and 2-oxobutanoate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that reversibly catalyze the oxidative decarboxylation of different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.3.
Cross-references
BRENDA 1.2.7.7
EC2PDB 1.2.7.7
ExplorEnz 1.2.7.7
PRIAM enzyme-specific profiles 1.2.7.7
KEGG Ligand Database for Enzyme Nomenclature 1.2.7.7
IUBMB Enzyme Nomenclature 1.2.7.7
IntEnz 1.2.7.7
MEDLINE Find literature relating to 1.2.7.7
MetaCyc 1.2.7.7
Rhea expert-curated reactions 1.2.7.7
UniProtKB/Swiss-Prot
Q9UYY9, PORC_PYRAB P84819, PORC_PYREN Q51799, PORC_PYRFU
O58411, PORC_PYRHO Q5JIK2, PORC_THEKO P84820, PORC_THELN
O26801, VORA_METTH Q9UYZ1, VORA_PYRAB Q51801, VORA_PYRFU
O58413, VORA_PYRHO O26800, VORB_METTH P80908, VORB_METTM
Q9UYZ2, VORB_PYRAB Q51802, VORB_PYRFU O58414, VORB_PYRHO
O26799, VORC_METTH P80909, VORC_METTM Q9UYZ0, VORD_PYRAB
Q51800, VORD_PYRFU O58412, VORD_PYRHO

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