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ENZYME

ENZYME entry: EC 1.3.1.14

Accepted Name
dihydroorotate dehydrogenase (NAD(+))
Alternative Name(s)
DHOD
DHODase
DHOdehase
dihydroorotate oxidase
orotate reductase (NADH)
orotate reductase (NADH2)
Reaction catalysed
(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate
Comment(s)
  • The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
Cross-references
BRENDA 1.3.1.14
EC2PDB 1.3.1.14
ExplorEnz 1.3.1.14
PRIAM enzyme-specific profiles 1.3.1.14
KEGG Ligand Database for Enzyme Nomenclature 1.3.1.14
IUBMB Enzyme Nomenclature 1.3.1.14
IntEnz 1.3.1.14
MEDLINE Find literature relating to 1.3.1.14
MetaCyc 1.3.1.14
Rhea expert-curated reactions 1.3.1.14
UniProtKB/Swiss-Prot
A6TVS0, PYRDB_ALKMQ A8MIU4, PYRDB_ALKOO B7GFA1, PYRDB_ANOFW
O29513, PYRDB_ARCFU B6YRL9, PYRDB_AZOPC C3P654, PYRDB_BACAA
C3L742, PYRDB_BACAC A0RHQ6, PYRDB_BACAH Q81WF4, PYRDB_BACAN
B7JJX1, PYRDB_BACC0 Q732I5, PYRDB_BACC1 B7IUP4, PYRDB_BACC2
C1EPP8, PYRDB_BACC3 B7H6M0, PYRDB_BACC4 B7HLL8, PYRDB_BACC7
P46539, PYRDB_BACCL A7GRK9, PYRDB_BACCN B9IVW1, PYRDB_BACCQ
Q819S5, PYRDB_BACCR Q636E2, PYRDB_BACCZ Q5LCI2, PYRDB_BACFN
Q64TN0, PYRDB_BACFR Q6HET0, PYRDB_BACHK A9VTC4, PYRDB_BACMK
A8FD19, PYRDB_BACP2 P25996, PYRDB_BACSU Q8A9C3, PYRDB_BACTN
A7Z4H4, PYRDB_BACVZ C0QYH6, PYRDB_BRAHW B9MS26, PYRDB_CALBD
Q8R9R7, PYRDB_CALS4 A4XKT6, PYRDB_CALS8 Q3AC05, PYRDB_CARHZ
B5EFU4, PYRDB_CITBB Q18CS6, PYRDB_CLOD6 Q6A912, PYRDB_CUTAK
B1I4M6, PYRDB_DESAP A4J560, PYRDB_DESRM B1GYY3, PYRDB_ENDTX
P0DH74, PYRDB_ENTFA F2MMN9, PYRDB_ENTFO B1YIR7, PYRDB_EXIS2
Q8RG85, PYRDB_FUSNN B9M211, PYRDB_GEODF Q5L0U1, PYRDB_GEOKA
Q39UK4, PYRDB_GEOMG Q74CB9, PYRDB_GEOSL C6E6N2, PYRDB_GEOSM
C5D8Q2, PYRDB_GEOSW A4IM35, PYRDB_GEOTN A5G3H0, PYRDB_GEOUR
Q9K9W1, PYRDB_HALH5 B0TGQ8, PYRDB_HELMI Q9CFW8, PYRDB_LACLA
P54322, PYRDB_LACLM A9KKR5, PYRDB_LACP7 Q38X22, PYRDB_LATSS
Q92AH5, PYRDB_LISIN C1KWD2, PYRDB_LISMC Q71YI3, PYRDB_LISMF
B8DDR9, PYRDB_LISMH Q8Y667, PYRDB_LISMO A0AJT8, PYRDB_LISW6
Q8EUY2, PYRDB_MALP2 C6BW12, PYRDB_MARSD Q8TT55, PYRDB_METAC
Q0W8E1, PYRDB_METAR Q58070, PYRDB_METJA Q8TXU6, PYRDB_METKA
Q8PW56, PYRDB_METMA O27281, PYRDB_METTH B2A2U4, PYRDB_NATTJ
Q8CWG1, PYRDB_OCEIH A6LB11, PYRDB_PARD8 A1ASB3, PYRDB_PELPD
A9BJH4, PYRDB_PETMO A6L5H1, PYRDB_PHOV8 Q7MVJ6, PYRDB_PORGI
Q9V0Y6, PYRDB_PYRAB Q8U0P6, PYRDB_PYRFU O59185, PYRDB_PYRHO
Q9UX04, PYRDB_SACS2 Q5WFJ4, PYRDB_SHOC1 C4XPD6, PYRDB_SOLM1
B9DPN4, PYRDB_STACT Q97R65, PYRDB_STRPN Q8DQ37, PYRDB_STRR6
O08358, PYRDB_SULAC Q0AXG6, PYRDB_SYNWW Q9HL35, PYRDB_THEAC
Q5JHR7, PYRDB_THEKO Q9WYG8, PYRDB_THEMA A5IK84, PYRDB_THEP1
B0KA32, PYRDB_THEP3 B0K2E5, PYRDB_THEPX Q979G6, PYRDB_THEVO
B5YJH1, PYRDB_THEYD B3E4T4, PYRDB_TRIL1

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