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ENZYME

ENZYME entry: EC 1.3.1.48

Accepted Name
15-oxoprostaglandin 13-reductase
Alternative Name(s)
15-oxo-Delta(13)-prostaglandin reductase
prostaglandin 13-reductase
Reaction catalysed
  • 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH
  • 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxoprostaglandin E2 + H(+) + NADH
Comment(s)
  • Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives.
  • The enzyme from placenta is specific for NAD(+).
Cross-references
BRENDA 1.3.1.48
EC2PDB 1.3.1.48
ExplorEnz 1.3.1.48
PRIAM enzyme-specific profiles 1.3.1.48
KEGG Ligand Database for Enzyme Nomenclature 1.3.1.48
IUBMB Enzyme Nomenclature 1.3.1.48
IntEnz 1.3.1.48
MEDLINE Find literature relating to 1.3.1.48
MetaCyc 1.3.1.48
Rhea expert-curated reactions 1.3.1.48
UniProtKB/Swiss-Prot
Q3SZJ4, PTGR1_BOVIN Q9EQZ5, PTGR1_CAVPO Q14914, PTGR1_HUMAN
Q91YR9, PTGR1_MOUSE Q29073, PTGR1_PIG Q28719, PTGR1_RABIT
P97584, PTGR1_RAT Q32L99, PTGR2_BOVIN Q8N8N7, PTGR2_HUMAN
Q8VDQ1, PTGR2_MOUSE Q5R806, PTGR2_PONAB Q5BK81, PTGR2_RAT
Q24K16, PTGR3_BOVIN Q8N4Q0, PTGR3_HUMAN Q8BGC4, PTGR3_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
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