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ENZYME

ENZYME entry: EC 1.3.1.76

Accepted Name
precorrin-2 dehydrogenase
Alternative Name(s)
precorrin-2 oxidase
Reaction catalysed
NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin
Comment(s)
  • Catalyzes the second of three steps leading to the formation of siroheme from uroporphyrinogen III.
  • The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4).
  • In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.
  • In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction.
Cross-references
BRENDA 1.3.1.76
EC2PDB 1.3.1.76
ExplorEnz 1.3.1.76
PRIAM enzyme-specific profiles 1.3.1.76
KEGG Ligand Database for Enzyme Nomenclature 1.3.1.76
IUBMB Enzyme Nomenclature 1.3.1.76
IntEnz 1.3.1.76
MEDLINE Find literature relating to 1.3.1.76
MetaCyc 1.3.1.76
Rhea expert-curated reactions 1.3.1.76
UniProtKB/Swiss-Prot
A0KLD7, CYSG1_AERHH A4SHL4, CYSG1_AERS4 A7MJ67, CYSG1_CROS8
A1WWP8, CYSG1_HALHL A6TD45, CYSG1_KLEP7 Q6D1A4, CYSG1_PECAS
A8G9Y3, CYSG1_SERP5 A1JJS8, CYSG1_YERE8 A7FLY4, CYSG1_YERP3
Q1CLS2, CYSG1_YERPN A4TGU8, CYSG1_YERPP Q66EC9, CYSG1_YERPS
A0KP37, CYSG2_AERHH A4SRH0, CYSG2_AERS4 A7MKK9, CYSG2_CROS8
A1WYD5, CYSG2_HALHL A6TF07, CYSG2_KLEP7 Q6CZS0, CYSG2_PECAS
A8GKQ1, CYSG2_SERP5 A1JSB7, CYSG2_YERE8 A7FNS9, CYSG2_YERP3
Q1CCP6, CYSG2_YERPN A4TPZ1, CYSG2_YERPP Q664M6, CYSG2_YERPS
A0KQJ4, CYSG3_AERHH Q6F8G6, CYSG_ACIAD B3GZA0, CYSG_ACTP7
B0BTC2, CYSG_ACTPJ A6VPZ6, CYSG_ACTSZ Q0VQ05, CYSG_ALCBS
Q0A812, CYSG_ALKEH C1DKY7, CYSG_AZOVD Q1LTP4, CYSG_BAUCH
Q7VQG9, CYSG_BLOFL Q493N1, CYSG_BLOPB Q2KWB0, CYSG_BORA1
Q7WMM4, CYSG_BORBR Q7WB57, CYSG_BORPA A9HZV6, CYSG_BORPD
Q7VZ77, CYSG_BORPE P57500, CYSG_BUCAI Q7NZV7, CYSG_CHRVO
A8AQS4, CYSG_CITK8 A7ZSP4, CYSG_ECO24 B7UK79, CYSG_ECO27
B7MCY5, CYSG_ECO45 B7L4P2, CYSG_ECO55 P0AEA9, CYSG_ECO57
B5YTS6, CYSG_ECO5E B7NMD7, CYSG_ECO7I B7N1F1, CYSG_ECO81
B7M1S1, CYSG_ECO8A C4ZUM4, CYSG_ECOBW B1X716, CYSG_ECODH
A8A5H5, CYSG_ECOHS A1AGQ2, CYSG_ECOK1 Q0TC92, CYSG_ECOL5
Q8FCW8, CYSG_ECOL6 B1IP96, CYSG_ECOLC P0AEA8, CYSG_ECOLI
B7NDX8, CYSG_ECOLU B6I2S7, CYSG_ECOSE B1LHG9, CYSG_ECOSM
Q1R5R3, CYSG_ECOUT C5BGP8, CYSG_EDWI9 A4WFH1, CYSG_ENT38
B7LS75, CYSG_ESCF3 A9H259, CYSG_GLUDA Q5FP95, CYSG_GLUOX
Q2SJB7, CYSG_HAHCH Q31GG8, CYSG_HYDCU Q65T49, CYSG_MANSM
Q606C9, CYSG_METCA Q1H3L5, CYSG_METFK A9LZ77, CYSG_NEIM0
P57001, CYSG_NEIMA P95370, CYSG_NEIMB A1KU10, CYSG_NEIMF
Q0AHC1, CYSG_NITEC Q820Q4, CYSG_NITEU Q2Y6L7, CYSG_NITMU
Q3JCS0, CYSG_NITOC Q7N8L2, CYSG_PHOLL Q6LM67, CYSG_PHOPR
Q48H75, CYSG_PSE14 Q15YU1, CYSG_PSEA6 A6V4H6, CYSG_PSEA7
B7UW11, CYSG_PSEA8 Q02NA3, CYSG_PSEAB Q9I0M7, CYSG_PSEAE
Q1IBC9, CYSG_PSEE4 Q4K9V8, CYSG_PSEF5 C3JY53, CYSG_PSEFS
A4XUX3, CYSG_PSEMY A5W1H7, CYSG_PSEP1 Q3KA85, CYSG_PSEPF
Q88FT3, CYSG_PSEPK B1JBD9, CYSG_PSEPW Q87ZT0, CYSG_PSESM
Q3ILQ9, CYSG_PSET1 Q4ZRL6, CYSG_PSEU2 Q4FSU1, CYSG_PSYA2
Q1QAX7, CYSG_PSYCK A1SRP9, CYSG_PSYIN A5WEG6, CYSG_PSYWF
A1AVU5, CYSG_RUTMC Q21K21, CYSG_SACD2 B5F8J0, CYSG_SALA4
A9MME5, CYSG_SALAR Q57IZ5, CYSG_SALCH B5FJQ1, CYSG_SALDC
B5R2C7, CYSG_SALEP B5R7N6, CYSG_SALG2 B4TKQ4, CYSG_SALHS
B4SVI1, CYSG_SALNS Q5PLV8, CYSG_SALPA A9MT45, CYSG_SALPB
C0Q0F3, CYSG_SALPC B5BH22, CYSG_SALPK B4TY38, CYSG_SALSV
Q8Z201, CYSG_SALTI P25924, CYSG_SALTY B2U3H4, CYSG_SHIB3
Q31VS0, CYSG_SHIBS Q32AZ8, CYSG_SHIDS Q0SZU8, CYSG_SHIF8
Q83JB3, CYSG_SHIFL Q3YWQ3, CYSG_SHISS Q2NVN0, CYSG_SODGM
A4VLU6, CYSG_STUS1 Q3SG32, CYSG_THIDA B8GUD3, CYSG_THISH
C4LAG5, CYSG_TOLAT A5CXE4, CYSG_VESOH B2I985, CYSG_XYLF2
Q9PF46, CYSG_XYLFA B0U4X0, CYSG_XYLFM Q87AI5, CYSG_XYLFT
Q1C2P9, CYSG_YERPA Q74Y23, CYSG_YERPE Q5NRM4, CYSG_ZYMMO
Q59292, HEMA_RUMJO O14172, MET8_SCHPO P15807, MET8_YEAST
Q46CH4, PC2DH_METBF Q57605, PC2DH_METJA O34813, SIRC_BACSU
P61818, SIRC_PRIMG

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
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