Expasy logo

ENZYME

ENZYME entry: EC 1.3.5.2

Accepted Name
dihydroorotate dehydrogenase (quinone)
Alternative Name(s)
DHOD
DHOdehase
DHODH
Reaction catalysed
(S)-dihydroorotate + a quinone <=> a quinol + orotate
Comment(s)
  • This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
  • The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane.
  • The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates.
  • Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not.
  • Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • Formerly EC 1.3.99.11.
Cross-references
BRENDA 1.3.5.2
EC2PDB 1.3.5.2
ExplorEnz 1.3.5.2
PRIAM enzyme-specific profiles 1.3.5.2
KEGG Ligand Database for Enzyme Nomenclature 1.3.5.2
IUBMB Enzyme Nomenclature 1.3.5.2
IntEnz 1.3.5.2
MEDLINE Find literature relating to 1.3.5.2
MetaCyc 1.3.5.2
Rhea expert-curated reactions 1.3.5.2
UniProtKB/Swiss-Prot
Q6CTX8, PYRD2_KLULA Q6SZS6, PYRD2_KLUMA B0CA74, PYRD_ACAM1
Q6FCL9, PYRD_ACIAD B7GZW7, PYRD_ACIB3 B7I2L5, PYRD_ACIB5
B2HUT6, PYRD_ACIBC B0VKB8, PYRD_ACIBS A3M6Y2, PYRD_ACIBT
B0V824, PYRD_ACIBY B9MIU2, PYRD_ACIET B7J5Q1, PYRD_ACIF2
B5EL46, PYRD_ACIF5 A1W7S6, PYRD_ACISJ A3N0D6, PYRD_ACTP2
B3H1B5, PYRD_ACTP7 B0BP55, PYRD_ACTPJ A6VP48, PYRD_ACTSZ
A0KKK9, PYRD_AERHH A4SME2, PYRD_AERS4 A9CK85, PYRD_AGRFC
B2UNA2, PYRD_AKKM8 Q21WC4, PYRD_ALBFT Q5E5B6, PYRD_ALIF1
B5FE17, PYRD_ALIFM B6ELD1, PYRD_ALISL Q0A8M5, PYRD_ALKEH
B9JR03, PYRD_ALLAM B8JDF0, PYRD_ANAD2 Q2IQI6, PYRD_ANADE
A7HD76, PYRD_ANADF B4UG99, PYRD_ANASK P32746, PYRD_ARATH
Q5P1A9, PYRD_AROAE A0JX31, PYRD_ARTS2 A8HZX8, PYRD_AZOC5
A1K7M2, PYRD_AZOSB C1DDY1, PYRD_AZOVD A1URL3, PYRD_BARBK
Q6G4F7, PYRD_BARHE Q6G159, PYRD_BARQU A9IQ81, PYRD_BART1
Q1LT62, PYRD_BAUCH Q2KW44, PYRD_BORA1 Q7WGE4, PYRD_BORBR
Q7W4W6, PYRD_BORPA A9I8M0, PYRD_BORPD Q7VTR9, PYRD_BORPE
Q5E9W3, PYRD_BOVIN Q89VA7, PYRD_BRADU A5EA61, PYRD_BRASB
A4Z2G7, PYRD_BRASO B2S953, PYRD_BRUA1 Q2YPG3, PYRD_BRUA2
A6WVY1, PYRD_BRUA4 Q57F47, PYRD_BRUAB A9M7Z9, PYRD_BRUC2
C0RH28, PYRD_BRUMB Q8YFB1, PYRD_BRUME A5VNQ1, PYRD_BRUO2
B0CJU0, PYRD_BRUSI Q8G2K8, PYRD_BRUSU P57443, PYRD_BUCAI
Q8K9I5, PYRD_BUCAP A0K729, PYRD_BURCH B4E8N4, PYRD_BURCJ
Q0BFR0, PYRD_BURCM Q39GX5, PYRD_BURL3 A9AJX4, PYRD_BURM1
A3MJ98, PYRD_BURM7 A2S374, PYRD_BURM9 Q62K45, PYRD_BURMA
A1V4A5, PYRD_BURMS Q1BWM4, PYRD_BURO1 A3NUS1, PYRD_BURP0
Q3JSS8, PYRD_BURP1 A3N925, PYRD_BURP6 Q63TV1, PYRD_BURPS
Q2SVL9, PYRD_BURTA Q874I4, PYRD_CANAL Q6SZS5, PYRD_CANGA
B3PIL8, PYRD_CELJU A3PN03, PYRD_CERS1 Q3IZ94, PYRD_CERS4
B9KNA2, PYRD_CERSK Q11M76, PYRD_CHESB A9WDI1, PYRD_CHLAA
B9LHC1, PYRD_CHLSY A0M4D0, PYRD_CHRFK Q7NX17, PYRD_CHRVO
A8AID4, PYRD_CITK8 A5CS38, PYRD_CLAM3 B0RIK6, PYRD_CLAMS
Q480K7, PYRD_COLP3 Q6NH79, PYRD_CORDI Q8FTC6, PYRD_COREF
A4QEA4, PYRD_CORGB Q8NQC0, PYRD_CORGL Q9FB59, PYRD_CORST
B6J754, PYRD_COXB1 B6J0A5, PYRD_COXB2 A9KCF2, PYRD_COXBN
A9NCV1, PYRD_COXBR Q83CY0, PYRD_COXBU B1WUM4, PYRD_CROS5
A7MEW0, PYRD_CROS8 Q1LP27, PYRD_CUPMC Q0KBT4, PYRD_CUPNH
Q472J6, PYRD_CUPPJ B3R4T0, PYRD_CUPTR B8HW33, PYRD_CYAP4
P28294, PYRD_CYCAE Q47GW1, PYRD_DECAR C1CX89, PYRD_DEIDV
Q1J132, PYRD_DEIGD Q9RX14, PYRD_DEIRA A9BWU2, PYRD_DELAS
A5EV79, PYRD_DICNV P32748, PYRD_DROME A7ZK49, PYRD_ECO24
B7UN24, PYRD_ECO27 B7MHP7, PYRD_ECO45 B7LE45, PYRD_ECO55
P0A7E2, PYRD_ECO57 B5YT76, PYRD_ECO5E B7NM29, PYRD_ECO7I
B7MS56, PYRD_ECO81 B7M874, PYRD_ECO8A C4ZQ71, PYRD_ECOBW
B1X8P9, PYRD_ECODH A7ZYP7, PYRD_ECOHS A1A9L5, PYRD_ECOK1
Q0TJB6, PYRD_ECOL5 Q8FJ91, PYRD_ECOL6 B1IVY7, PYRD_ECOLC
P0A7E1, PYRD_ECOLI B7N3A7, PYRD_ECOLU B6I919, PYRD_ECOSE
B1LJR7, PYRD_ECOSM Q1RDR9, PYRD_ECOUT C5BD71, PYRD_EDWI9
A4W8V7, PYRD_ENT38 Q75CE1, PYRD_EREGS B2VC84, PYRD_ERWT9
Q2N6N6, PYRD_ERYLH B7LNV5, PYRD_ESCF3 A5FHT2, PYRD_FLAJ1
Q9F1U7, PYRD_FLALU A6H0L5, PYRD_FLAPJ B8F848, PYRD_GLAP5
B7KIU7, PYRD_GLOC7 Q7NC99, PYRD_GLOVI Q7VL56, PYRD_HAEDU
Q4QKB5, PYRD_HAEI8 A5UC11, PYRD_HAEIE A5UEP8, PYRD_HAEIG
P45477, PYRD_HAEIN Q2SCG9, PYRD_HAHCH A1WTJ3, PYRD_HALHL
Q5UYF1, PYRD_HALMA B0R808, PYRD_HALS3 Q9HMK2, PYRD_HALSA
C4K4A3, PYRD_HAMD5 Q17WU9, PYRD_HELAH B6JL11, PYRD_HELP2
B5Z6I2, PYRD_HELPG Q1CU70, PYRD_HELPH Q9ZM11, PYRD_HELPJ
B2USR9, PYRD_HELPS O25655, PYRD_HELPY A4G7T7, PYRD_HERAR
Q02127, PYRD_HUMAN Q5QX65, PYRD_IDILO A6T106, PYRD_JANMA
A6WD43, PYRD_KINRD B5XY59, PYRD_KLEP3 A6T739, PYRD_KLEP7
B2GHT4, PYRD_KOCRD Q6V3W9, PYRD_LACK1 Q5X496, PYRD_LEGPA
A5ICX8, PYRD_LEGPC Q5ZUH7, PYRD_LEGPH Q5WVN0, PYRD_LEGPL
Q6AE78, PYRD_LEIXX B1Y3C1, PYRD_LEPCP Q65TR8, PYRD_MANSM
A6VW35, PYRD_MARMS A1TZG0, PYRD_MARN8 B7KZJ5, PYRD_METC4
Q609J2, PYRD_METCA Q1H411, PYRD_METFK B3DX48, PYRD_METI4
B8ID11, PYRD_METNO A2SHQ5, PYRD_METPP O35435, PYRD_MOUSE
B1MPD4, PYRD_MYCA9 P65909, PYRD_MYCBO A1KKI2, PYRD_MYCBP
C1AQ55, PYRD_MYCBT A4TB97, PYRD_MYCGI P46727, PYRD_MYCLE
B2HFZ1, PYRD_MYCMM Q73YS2, PYRD_MYCPA A0QZY9, PYRD_MYCS2
A3Q1C6, PYRD_MYCSJ A1UHW0, PYRD_MYCSK Q1B765, PYRD_MYCSS
A5U4G5, PYRD_MYCTA P9WHL0, PYRD_MYCTO P9WHL1, PYRD_MYCTU
A0PQW5, PYRD_MYCUA A1TAT2, PYRD_MYCVP Q1D7Y6, PYRD_MYXXD
Q3IU78, PYRD_NATPD B9L9P6, PYRD_NAUPA Q5F605, PYRD_NEIG1
A9M3G1, PYRD_NEIM0 Q9JX66, PYRD_NEIMA Q9K1D7, PYRD_NEIMB
A1KRQ4, PYRD_NEIMF Q0AIB4, PYRD_NITEC Q82ST3, PYRD_NITEU
Q2Y5H8, PYRD_NITMU A6Q2V6, PYRD_NITSB Q5YVM8, PYRD_NOCFA
A1SJF2, PYRD_NOCSJ B2IU79, PYRD_NOSP7 Q8YPC6, PYRD_NOSS1
Q2GBY1, PYRD_NOVAD Q7XKC8, PYRD_ORYSJ A1TPZ2, PYRD_PARC0
A7HQ77, PYRD_PARL1 Q7U3U2, PYRD_PARMW B2JKL9, PYRD_PARP8
Q13ZM3, PYRD_PARXL P57858, PYRD_PASMU Q6D456, PYRD_PECAS
C6DFC0, PYRD_PECCP Q7N617, PYRD_PHOLL Q6LRA2, PYRD_PHOPR
Q08210, PYRD_PLAF7 A4SWU5, PYRD_POLAQ A1VQJ1, PYRD_POLNA
B1XV77, PYRD_POLNS Q129L9, PYRD_POLSJ Q5R6X6, PYRD_PONAB
B4EVC3, PYRD_PROMH Q7V473, PYRD_PROMM Q48JY0, PYRD_PSE14
Q15UB7, PYRD_PSEA6 A6V325, PYRD_PSEA7 B7UWL8, PYRD_PSEA8
Q02PL5, PYRD_PSEAB Q9HZF8, PYRD_PSEAE B8H8Q4, PYRD_PSECP
Q1ICL4, PYRD_PSEE4 Q4KFI7, PYRD_PSEF5 C3K017, PYRD_PSEFS
A4XWQ0, PYRD_PSEMY Q3KFC7, PYRD_PSEPF B0KG90, PYRD_PSEPG
Q88L40, PYRD_PSEPK B1J5B5, PYRD_PSEPW Q883P1, PYRD_PSESM
Q3IGZ1, PYRD_PSET1 Q4ZUM3, PYRD_PSEU2 Q4FS74, PYRD_PSYA2
Q1QBS1, PYRD_PSYCK A1SX25, PYRD_PSYIN A5WDZ3, PYRD_PSYWF
Q8XYY7, PYRD_RALN1 Q63707, PYRD_RAT B3PNN8, PYRD_RHIE6
Q2KCS8, PYRD_RHIEC Q1MLT8, PYRD_RHIJ3 Q98B89, PYRD_RHILO
B5ZPH6, PYRD_RHILW Q92S77, PYRD_RHIME B9J901, PYRD_RHIR8
C0ZZY4, PYRD_RHOE4 C1ASU1, PYRD_RHOOB Q2IR55, PYRD_RHOP2
Q07TQ6, PYRD_RHOP5 Q6NBN1, PYRD_RHOPA Q13D13, PYRD_RHOPS
B3QEE3, PYRD_RHOPT Q2RX27, PYRD_RHORT B7JXU8, PYRD_RIPO1
A7NLW9, PYRD_ROSCS A5UX75, PYRD_ROSS1 Q21JW9, PYRD_SACD2
B5F1U2, PYRD_SALA4 A8LY18, PYRD_SALAI A9MHU3, PYRD_SALAR
Q57QU4, PYRD_SALCH B5FQY8, PYRD_SALDC B5QZE8, PYRD_SALEP
B5R8M3, PYRD_SALG2 B4TDY5, PYRD_SALHS B4T1Y8, PYRD_SALNS
Q5PGE0, PYRD_SALPA A9N6Y4, PYRD_SALPB C0PVS5, PYRD_SALPC
B5BBM2, PYRD_SALPK B4TRW8, PYRD_SALSV Q8Z7S9, PYRD_SALTI
A4X619, PYRD_SALTO P25468, PYRD_SALTY P32747, PYRD_SCHPO
A8GCK4, PYRD_SERP5 A1S5Z4, PYRD_SHEAM B8E984, PYRD_SHEB2
A3D5B9, PYRD_SHEB5 A6WP30, PYRD_SHEB8 A9L4D0, PYRD_SHEB9
Q12NG2, PYRD_SHEDO Q081J9, PYRD_SHEFN B0TIY0, PYRD_SHEHH
A3QDX8, PYRD_SHELP Q8EDZ8, PYRD_SHEON A8H3X8, PYRD_SHEPA
A4Y7I2, PYRD_SHEPC B8CPG0, PYRD_SHEPW A0KW50, PYRD_SHESA
A8FW61, PYRD_SHESH Q0HJL0, PYRD_SHESM Q0HVV6, PYRD_SHESR
A1RJ06, PYRD_SHESW B1KDM8, PYRD_SHEWM B2TUD4, PYRD_SHIB3
Q31YK8, PYRD_SHIBS Q32HW1, PYRD_SHIDS Q0T689, PYRD_SHIF8
Q83RX6, PYRD_SHIFL Q3Z3H6, PYRD_SHISS C3MFT0, PYRD_SINFN
A6U5U0, PYRD_SINMW Q2NU82, PYRD_SODGM Q1GVC1, PYRD_SPHAL
Q827Q6, PYRD_STRAW Q9KXR7, PYRD_STRCO B1W464, PYRD_STRGG
B4STK4, PYRD_STRM5 B2FPI7, PYRD_STRMK A4VM41, PYRD_STUS1
Q30R79, PYRD_SULDN A6Q8G0, PYRD_SULNB Q31RJ7, PYRD_SYNE7
Q2JRL7, PYRD_SYNJA Q2JJF3, PYRD_SYNJB Q5N2Q8, PYRD_SYNP6
P74782, PYRD_SYNY3 C5BKZ2, PYRD_TERTT Q47RF2, PYRD_THEFY
Q72KU3, PYRD_THET2 Q5SK69, PYRD_THET8 Q8DLB7, PYRD_THEVB
Q3SL21, PYRD_THIDA Q113R9, PYRD_TRIEI Q3MDU0, PYRD_TRIV2
A1WJ81, PYRD_VEREI B7VNK9, PYRD_VIBA3 A7N0L2, PYRD_VIBC1
A5F839, PYRD_VIBC3 Q9KRZ2, PYRD_VIBCH C3LMH4, PYRD_VIBCM
Q87PB7, PYRD_VIBPA Q8D9G5, PYRD_VIBVU Q7MKX3, PYRD_VIBVY
Q8D370, PYRD_WIGBR Q8PLJ2, PYRD_XANAC Q3BUJ7, PYRD_XANC5
Q4UTX5, PYRD_XANC8 B0RTS3, PYRD_XANCB Q8P9R0, PYRD_XANCP
Q2P3M0, PYRD_XANOM B2SLB9, PYRD_XANOP Q5H0N0, PYRD_XANOR
A7IBC2, PYRD_XANP2 B2I9T5, PYRD_XYLF2 Q9PAE7, PYRD_XYLFA
B0U5I1, PYRD_XYLFM Q87A77, PYRD_XYLFT A1JMP8, PYRD_YERE8
A7FJU2, PYRD_YERP3 Q1CA44, PYRD_YERPA B2JYR8, PYRD_YERPB
Q8ZG91, PYRD_YERPE A9R7L2, PYRD_YERPG Q1CGJ0, PYRD_YERPN
A4TMZ3, PYRD_YERPP Q66CG4, PYRD_YERPS B1JQS0, PYRD_YERPY

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-