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ENZYME

ENZYME entry: EC 1.3.7.5

Accepted Name
phycocyanobilin:ferredoxin oxidoreductase
Reaction catalysed
(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • Catalyzes the four-electron reduction of biliverdin IXalpha (2-electron reduction at both the A and D rings).
  • Reaction proceeds via an isolatable 2-electron intermediate, 18(1),18(2)-dihydrobiliverdin.
  • Flavodoxins can be used instead of ferredoxin.
  • The direct conversion of biliverdin IXalpha (BV) to (3Z)- phycocyanobilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate.
Cross-references
BRENDA 1.3.7.5
EC2PDB 1.3.7.5
ExplorEnz 1.3.7.5
PRIAM enzyme-specific profiles 1.3.7.5
KEGG Ligand Database for Enzyme Nomenclature 1.3.7.5
IUBMB Enzyme Nomenclature 1.3.7.5
IntEnz 1.3.7.5
MEDLINE Find literature relating to 1.3.7.5
MetaCyc 1.3.7.5
Rhea expert-curated reactions 1.3.7.5
UniProtKB/Swiss-Prot
B1X018, PCYA_CROS5 B7KJQ2, PCYA_GLOC7 Q7NHE8, PCYA_GLOVI
B0JPG5, PCYA_MICAN Q93TM9, PCYA_NOSP7 Q93TN0, PCYA_NOSS1
Q7U7A1, PCYA_PARMW A3PCF5, PCYA_PROM0 A8G4C5, PCYA_PROM2
A2CA92, PCYA_PROM3 A2BW83, PCYA_PROM5 Q31BD0, PCYA_PROM9
Q7VCC2, PCYA_PROMA Q7V7Y8, PCYA_PROMM Q93TL5, PCYA_PROMP
A2BQN3, PCYA_PROMS B7JWS2, PCYA_RIPO1 Q8KPS9, PCYA_SYNE7
Q5N5A3, PCYA_SYNP6 Q3AXI3, PCYA_SYNS9 Q3AKB1, PCYA_SYNSC
Q55891, PCYA_SYNY3 P59288, PCYA_THEVB Q10X61, PCYA_TRIEI
Q3M745, PCYA_TRIV2

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