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ENZYME

ENZYME entry: EC 1.4.1.24

Accepted Name
3-dehydroquinate synthase II
Alternative Name(s)
DHQ synthase II
Reaction catalysed
2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)
Comment(s)
  • The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme catalyzes a two-step reaction - an oxidative deamination, followed by cyclization.
Cross-references
BRENDA 1.4.1.24
EC2PDB 1.4.1.24
ExplorEnz 1.4.1.24
PRIAM enzyme-specific profiles 1.4.1.24
KEGG Ligand Database for Enzyme Nomenclature 1.4.1.24
IUBMB Enzyme Nomenclature 1.4.1.24
IntEnz 1.4.1.24
MEDLINE Find literature relating to 1.4.1.24
MetaCyc 1.4.1.24
Rhea expert-curated reactions 1.4.1.24
UniProtKB/Swiss-Prot
O30010, DHQS_ARCFU A0RU27, DHQS_CENSY Q5V143, DHQS_HALMA
B0R336, DHQS_HALS3 Q9HSB6, DHQS_HALSA Q18DY6, DHQS_HALWD
B1L5W7, DHQS_KORCO A6UW69, DHQS_META3 Q8THC5, DHQS_METAC
Q0W131, DHQS_METAR A7I8L5, DHQS_METB6 Q46DZ8, DHQS_METBF
Q12UJ7, DHQS_METBU Q2FQ51, DHQS_METHJ Q58646, DHQS_METJA
Q8TVI1, DHQS_METKA A2SU08, DHQS_METLZ A4G0J1, DHQS_METM5
A9A8T5, DHQS_METM6 A6VHZ4, DHQS_METM7 Q8PXE8, DHQS_METMA
A3CV31, DHQS_METMJ Q6M1B0, DHQS_METMP B8GF73, DHQS_METPE
A5UJ82, DHQS_METS3 Q2NI00, DHQS_METST O26680, DHQS_METTH
A0B6K6, DHQS_METTP A6URJ1, DHQS_METVS Q3IRN3, DHQS_NATPD
A9A235, DHQS_NITMS

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