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ENZYME

ENZYME entry: EC 1.4.3.16

Accepted Name
L-aspartate oxidase
Alternative Name(s)
LASPO
Reaction catalysed
L-aspartate + O2 <=> H2O2 + iminosuccinate
Comment(s)
  • L-Aspartate oxidase catalyzes the first step in the de novo biosynthesis of NAD(+) in some bacteria.
  • O2 can be replaced by fumarate as electron acceptor, yielding succinate.
  • The ability of the enzyme to use both O2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions.
  • Iminosuccinate can either be hydrolyzed to form oxaloacetate and NH3 or can be used by EC 2.5.1.72 in the production of quinolinate.
Cross-references
BRENDA 1.4.3.16
EC2PDB 1.4.3.16
ExplorEnz 1.4.3.16
PRIAM enzyme-specific profiles 1.4.3.16
KEGG Ligand Database for Enzyme Nomenclature 1.4.3.16
IUBMB Enzyme Nomenclature 1.4.3.16
IntEnz 1.4.3.16
MEDLINE Find literature relating to 1.4.3.16
MetaCyc 1.4.3.16
Rhea expert-curated reactions 1.4.3.16
UniProtKB/Swiss-Prot
A0A1S3YEG8, AO2A_TOBAC A0A1S4BJT3, AO2B_TOBAC Q8XWM7, NADB1_RALN1
Q8XQG4, NADB2_RALN1 Q6F9B6, NADB_ACIAD Q8U8J4, NADB_AGRFC
O66973, NADB_AQUAE Q94AY1, NADB_ARATH P38032, NADB_BACSU
Q9A4C3, NADB_CAUVC Q97K95, NADB_CLOAB Q8XNE2, NADB_CLOPE
Q8XA23, NADB_ECO57 P10902, NADB_ECOLI Q9KDJ5, NADB_HALH5
Q9HNZ0, NADB_HALSA Q929Z2, NADB_LISIN Q8Y5N4, NADB_LISMO
P65500, NADB_MYCBO Q49617, NADB_MYCLE P9WJJ8, NADB_MYCTO
P9WJJ9, NADB_MYCTU Q9JSX4, NADB_NEIMA Q9K107, NADB_NEIMB
Q8YXJ6, NADB_NOSS1 Q6Z836, NADB_ORYSJ Q51363, NADB_PSEAE
Q9V2R0, NADB_PYRAB Q8TZL4, NADB_PYRFU O57765, NADB_PYRHO
Q98AV8, NADB_RHILO Q92R32, NADB_RHIME Q59767, NADB_RHORU
Q97ZC5, NADB_SACS2 Q8Z4K0, NADB_SALTI Q8ZMX9, NADB_SALTY
Q9X8N8, NADB_STRCO Q972D2, NADB_SULTO P74562, NADB_SYNY3
Q9KPA4, NADB_VIBCH Q9PC57, NADB_XYLFA Q87D19, NADB_XYLFT
Q8ZD80, NADB_YERPE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
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