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ENZYME

ENZYME entry: EC 1.4.7.1

Accepted Name
glutamate synthase (ferredoxin)
Alternative Name(s)
ferredoxin-dependent glutamate synthase
Reaction catalysed
2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • The protein is composed of two domains, one hydrolyzing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate.
  • The NH3 is channeled through a 24 A channel in the active protein.
  • No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein.
Cross-references
BRENDA 1.4.7.1
EC2PDB 1.4.7.1
ExplorEnz 1.4.7.1
PRIAM enzyme-specific profiles 1.4.7.1
KEGG Ligand Database for Enzyme Nomenclature 1.4.7.1
IUBMB Enzyme Nomenclature 1.4.7.1
IntEnz 1.4.7.1
MEDLINE Find literature relating to 1.4.7.1
MetaCyc 1.4.7.1
Rhea expert-curated reactions 1.4.7.1
UniProtKB/Swiss-Prot
Q9ZNZ7, GLTB1_ARATH Q9T0P4, GLTB2_ARATH Q06434, GLTB_ANTSP
O19906, GLTB_CYACA Q08258, GLTB_HORVU P23225, GLTB_MAIZE
Q1XDB2, GLTB_NEOYE Q69RJ0, GLTB_ORYSJ P51375, GLTB_PORPU
Q43155, GLTB_SPIOL P55037, GLTB_SYNY3 P55038, GLTS_SYNY3

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