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ENZYME

ENZYME entry: EC 1.5.3.6

Accepted Name
(R)-6-hydroxynicotine oxidase
Alternative Name(s)
6-hydroxy-D-nicotine oxidase
D-6-hydroxynicotine oxidase
Reaction catalysed
(R)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2
Comment(s)
  • The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)- nicotine.
  • The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyzes a similar reaction with the (S)-isomer (cf. EC 1.5.3.5).
Cross-references
BRENDA 1.5.3.6
EC2PDB 1.5.3.6
ExplorEnz 1.5.3.6
PRIAM enzyme-specific profiles 1.5.3.6
KEGG Ligand Database for Enzyme Nomenclature 1.5.3.6
IUBMB Enzyme Nomenclature 1.5.3.6
IntEnz 1.5.3.6
MEDLINE Find literature relating to 1.5.3.6
MetaCyc 1.5.3.6
Rhea expert-curated reactions 1.5.3.6
UniProtKB/Swiss-Prot
P08159, HDNO_PAENI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
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