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ENZYME

ENZYME entry: EC 1.5.99.12

Accepted Name
cytokinin dehydrogenase
Alternative Name(s)
cytokinin oxidase
Reaction catalysed
A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2
Comment(s)
  • Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is a prenyl group.
  • Although this activity was previously thought to be catalyzed by a hydrogen-peroxide-forming oxidase, this enzyme does not require oxygen for activity and does not form hydrogen peroxide.
  • 2,6-dichloroindophenol, methylene blue, nitroblue tetrazolium, phenazine methosulfate and copper(II) in the presence of imidazole can act as acceptors.
  • This enzyme plays a part in regulating rice-grain production, with lower levels of the enzyme resulting in enhanced grain production.
Cross-references
BRENDA 1.5.99.12
EC2PDB 1.5.99.12
ExplorEnz 1.5.99.12
PRIAM enzyme-specific profiles 1.5.99.12
KEGG Ligand Database for Enzyme Nomenclature 1.5.99.12
IUBMB Enzyme Nomenclature 1.5.99.12
IntEnz 1.5.99.12
MEDLINE Find literature relating to 1.5.99.12
MetaCyc 1.5.99.12
Rhea expert-curated reactions 1.5.99.12
UniProtKB/Swiss-Prot
Q5Z620, CKX10_ORYSJ Q6Z955, CKX11_ORYSJ O22213, CKX1_ARATH
Q9T0N8, CKX1_MAIZE Q0JQ12, CKX1_ORYSJ Q9FUJ3, CKX2_ARATH
Q4ADV8, CKX2_ORYSJ Q9LTS3, CKX3_ARATH Q8LNV6, CKX3_ORYSJ
Q9FUJ2, CKX4_ARATH Q5JLP4, CKX4_ORYSJ Q67YU0, CKX5_ARATH
Q5ZAY9, CKX5_ORYSJ Q9LY71, CKX6_ARATH Q6YW51, CKX6_ORYSJ
Q9FUJ1, CKX7_ARATH Q6YW50, CKX7_ORYSJ A2XVN3, CKX8_ORYSI
A3AVP1, CKX8_ORYSJ Q75K78, CKX9_ORYSJ P58763, CKX_WHEAT

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