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ENZYME

ENZYME entry: EC 1.6.2.4

Accepted Name
NADPH--hemoprotein reductase
Alternative Name(s)
aldehyde reductase (NADPH-dependent)
CPR
cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
cytochrome P450 reductase
dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
FAD-cytochrome c reductase
ferrihemoprotein P-450 reductase
NADP--cytochrome c reductase
NADP--cytochrome reductase
NADPH:ferrihemoprotein oxidoreductase
NADPH:P450 reductase
NADPH--cytochrome c oxidoreductase
NADPH--cytochrome c reductase
NADPH--cytochrome P450 oxidoreductase
NADPH--cytochrome P450 reductase
NADPH-dependent cytochrome c reductase
NADPH--ferricytochrome c oxidoreductase
NADPH--ferrihemoprotein reductase
reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
TPNH2 cytochrome c reductase
TPNH-cytochrome c reductase
Reaction catalysed
NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]
Comment(s)
  • This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN.
  • It also reduces cytochrome b5 and cytochrome c.
  • The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
Cross-references
BRENDA 1.6.2.4
EC2PDB 1.6.2.4
ExplorEnz 1.6.2.4
PRIAM enzyme-specific profiles 1.6.2.4
KEGG Ligand Database for Enzyme Nomenclature 1.6.2.4
IUBMB Enzyme Nomenclature 1.6.2.4
IntEnz 1.6.2.4
MEDLINE Find literature relating to 1.6.2.4
MetaCyc 1.6.2.4
Rhea expert-curated reactions 1.6.2.4
UniProtKB/Swiss-Prot
A0A3G9HRC2, ALT2_ALTAL Q81BF4, C102_BACCR Q2UNA2, C505_ASPOR
Q9Y8G7, C505_FUSOX A0A7T9QPQ1, CPR_PIPNI P14779, CPXB_PRIM2
A0A0C3HJL3, CYAG1_OIDMZ O08336, CYPB_BACSU I7ZK32, CYPC3_ASPO3
G5EJN7, CYPD6_PHACH O08394, CYPD_BACSU A2QLV1, CYPE1_ASPNC
Q0D1W9, CYPE3_ASPTN A0A0G4P2K0, CYPE4_PENC3 A0A0A2J1Z6, CYPE4_PENEN
A0A101MN42, CYPE4_PENFR G7XMT1, CYPE5_ASPKW A0A100IM63, CYPE5_ASPNG
G9MLG2, CYPP1_HYPVG R0IGL9, CYPU2_EXST2 Q9HGE0, FUM6_GIBM7
Q9SB48, NCPR1_ARATH A0A2U1LIM9, NCPR1_ARTAN Q7X7K8, NCPR1_ORYSJ
Q9SUM3, NCPR2_ARATH A0A2U1KZS6, NCPR2_ARTAN Q0J705, NCPR2_ORYSJ
Q653S9, NCPR3_ORYSJ Q4WM67, NCPR_ASPFU A2QS05, NCPR_ASPNC
Q00141, NCPR_ASPNG Q2UHA7, NCPR_ASPOR Q0CMM0, NCPR_ASPTN
Q3SYT8, NCPR_BOVIN P50126, NCPR_CANMA P37201, NCPR_CANTR
Q05001, NCPR_CATRO P37039, NCPR_CAVPO Q55CT1, NCPR_DICDI
Q27597, NCPR_DROME Q5BFT5, NCPR_EMENI P16435, NCPR_HUMAN
P37040, NCPR_MOUSE Q07994, NCPR_MUSDO Q9HDG2, NCPR_PHACH
P04175, NCPR_PIG P00389, NCPR_RABIT P00388, NCPR_RAT
P19618, NCPR_SALTR P36587, NCPR_SCHPO C5YJG8, NCPR_SORBI
P37116, NCPR_VIGRR P16603, NCPR_YEAST

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