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ENZYME

ENZYME entry: EC 1.6.3.1

Accepted Name
NAD(P)H oxidase (H2O2-forming)
Alternative Name(s)
dual oxidase
NAD(P)H oxidase
ThOX
THOX2
thyroid NADPH oxidase
thyroid oxidase
thyroid oxidase 2
Reaction catalysed
  • H(+) + NADPH + O2 <=> H2O2 + NADP(+)
  • H(+) + NADH + O2 <=> H2O2 + NAD(+)
Comment(s)
  • When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen.
  • The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups.
  • This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalyzed biosynthesis of thyroid hormones.
Cross-references
BRENDA 1.6.3.1
EC2PDB 1.6.3.1
ExplorEnz 1.6.3.1
PRIAM enzyme-specific profiles 1.6.3.1
KEGG Ligand Database for Enzyme Nomenclature 1.6.3.1
IUBMB Enzyme Nomenclature 1.6.3.1
IntEnz 1.6.3.1
MEDLINE Find literature relating to 1.6.3.1
MetaCyc 1.6.3.1
Rhea expert-curated reactions 1.6.3.1
UniProtKB/Swiss-Prot
O61213, DUOX1_CAEEL Q9MZF4, DUOX1_CANLF Q9NRD9, DUOX1_HUMAN
Q8HZK3, DUOX1_PIG Q8CIY2, DUOX1_RAT Q9NRD8, DUOX2_HUMAN
Q8HZK2, DUOX2_PIG Q9ES45, DUOX2_RAT Q9VQH2, DUOX_DROME
P49109, FMO5_CAVPO P49326, FMO5_HUMAN P97872, FMO5_MOUSE
Q04799, FMO5_RABIT Q8K4C0, FMO5_RAT F1MH07, MICA1_BOVIN
E7F9T0, MICA1_DANRE Q8TDZ2, MICA1_HUMAN Q8VDP3, MICA1_MOUSE
D3ZBP4, MICA1_RAT Q9NPH5, NOX4_HUMAN Q9JHI8, NOX4_MOUSE
Q5R5C5, NOX4_PONAB Q924V1, NOX4_RAT

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