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ENZYME

ENZYME entry: EC 1.6.5.2

Accepted Name
NAD(P)H dehydrogenase (quinone)
Alternative Name(s)
azoreductase
dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone)
diaphorase
DT-diaphorase
flavoprotein NAD(P)H-quinone reductase
menadione oxidoreductase
menadione reductase
NAD(P)H:(quinone-acceptor)oxidoreductase
NAD(P)H: menadione oxidoreductase
NAD(P)H2 dehydrogenase (quinone)
NAD(P)H dehydrogenase
NAD(P)H menadione reductase
NAD(P)H-quinone dehydrogenase
NAD(P)H-quinone oxidoreductase
NADH-menadione reductase
naphthoquinone reductase
p-benzoquinone reductase
phylloquinone reductase
quinone reductase
reduced NAD(P)H dehydrogenase
reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase
viologen accepting pyridine nucleotide oxidoreductase
vitamin K reductase
vitamin-K reductase
Reaction catalysed
  • a quinone + H(+) + NADH <=> a quinol + NAD(+)
  • a quinone + H(+) + NADPH <=> a quinol + NADP(+)
Comment(s)
  • The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone.
  • The animal, but not the plant, form of the enzyme is inhibited by dicoumarol.
  • Formerly EC 1.6.99.2.
Cross-references
BRENDA 1.6.5.2
EC2PDB 1.6.5.2
ExplorEnz 1.6.5.2
PRIAM enzyme-specific profiles 1.6.5.2
KEGG Ligand Database for Enzyme Nomenclature 1.6.5.2
IUBMB Enzyme Nomenclature 1.6.5.2
IntEnz 1.6.5.2
MEDLINE Find literature relating to 1.6.5.2
MetaCyc 1.6.5.2
Rhea expert-curated reactions 1.6.5.2
UniProtKB/Swiss-Prot
P74312, ARREH_SYNY3 P0AGE7, CHRR_ECO57 P0AGE6, CHRR_ECOLI
Q88FF8, CHRR_PSEPK Q93T20, CHRR_PSEPU P0AGE8, CHRR_SHIFL
Q9LSQ5, FQR1_ARATH Q6NQE2, FQRL1_ARATH O23207, FQRL2_ARATH
Q9LUX9, FQRL3_ARATH A8ALQ5, KEFF_CITK8 A7ZHD9, KEFF_ECO24
B7UI92, KEFF_ECO27 B7MAG9, KEFF_ECO45 B7L4G9, KEFF_ECO55
Q8XA24, KEFF_ECO57 B5YZ82, KEFF_ECO5E B7NHF0, KEFF_ECO7I
B7MNQ3, KEFF_ECO81 B7M0E3, KEFF_ECO8A C4ZPX2, KEFF_ECOBW
B1XC47, KEFF_ECODH A7ZVZ8, KEFF_ECOHS A1A795, KEFF_ECOK1
Q0TLU3, KEFF_ECOL5 P0A755, KEFF_ECOL6 B1IRD0, KEFF_ECOLC
P0A754, KEFF_ECOLI B7N7S1, KEFF_ECOLU B6HYZ7, KEFF_ECOSE
B1LFY0, KEFF_ECOSM Q1RGF2, KEFF_ECOUT A4W6F2, KEFF_ENT38
B7LVT7, KEFF_ESCF3 Q9X755, KEFF_KLEAE B5Y1Z9, KEFF_KLEP3
B5F766, KEFF_SALA4 A9MQG7, KEFF_SALAR Q57TH5, KEFF_SALCH
B5FI28, KEFF_SALDC B5R1S3, KEFF_SALEP B5RGB7, KEFF_SALG2
B4TII5, KEFF_SALHS B4T6L1, KEFF_SALNS C0Q4M9, KEFF_SALPC
B4TWT0, KEFF_SALSV Q8Z9K1, KEFF_SALTI Q8ZRW3, KEFF_SALTY
B2U254, KEFF_SHIB3 Q326I7, KEFF_SHIBS Q32K50, KEFF_SHIDS
Q0T8E9, KEFF_SHIF8 Q83SQ4, KEFF_SHIFL Q3Z5W3, KEFF_SHISS
A8AQP1, KEFG_CITK8 A7ME22, KEFG_CROS8 A7ZSM7, KEFG_ECO24
B7UK62, KEFG_ECO27 B7MCW7, KEFG_ECO45 B7L4M8, KEFG_ECO55
P0A758, KEFG_ECO57 B5YTQ8, KEFG_ECO5E B7NMB9, KEFG_ECO7I
B7N1D3, KEFG_ECO81 B7M1Q3, KEFG_ECO8A C4ZUK7, KEFG_ECOBW
B1X6K1, KEFG_ECODH A8A5F9, KEFG_ECOHS A1AGN7, KEFG_ECOK1
Q0TCA9, KEFG_ECOL5 P0A757, KEFG_ECOL6 B1IPB3, KEFG_ECOLC
P0A756, KEFG_ECOLI B7NDW0, KEFG_ECOLU B6I2R0, KEFG_ECOSE
Q1R5T1, KEFG_ECOUT A4WFE5, KEFG_ENT38 B2VK48, KEFG_ERWT9
B7LS58, KEFG_ESCF3 Q6CZU4, KEFG_PECAS C6DG98, KEFG_PECCP
B5F8H0, KEFG_SALA4 Q57J14, KEFG_SALCH B5FJN2, KEFG_SALDC
B5R2A9, KEFG_SALEP B5RGZ7, KEFG_SALG2 B4TKN3, KEFG_SALHS
B4SUV8, KEFG_SALNS Q5PL20, KEFG_SALPA A9MT18, KEFG_SALPB
C0Q0D4, KEFG_SALPC B5BH04, KEFG_SALPK B4TXG0, KEFG_SALSV
P65511, KEFG_SALTI P65510, KEFG_SALTY A8GKL4, KEFG_SERP5
Q32B14, KEFG_SHIDS Q0SZW5, KEFG_SHIF8 Q83PX9, KEFG_SHIFL
A1JS77, KEFG_YERE8 A7FNQ1, KEFG_YERP3 Q1C2S8, KEFG_YERPA
B2K5P7, KEFG_YERPB Q8ZJC5, KEFG_YERPE A9R474, KEFG_YERPG
Q1CCS6, KEFG_YERPN A4TGX4, KEFG_YERPP Q664Q4, KEFG_YERPS
B1JIU3, KEFG_YERPY P9WHH6, LPDA_MYCTO P9WHH7, LPDA_MYCTU
Q8CHK7, NQO1_CAVPO P15559, NQO1_HUMAN Q64669, NQO1_MOUSE
Q5RD31, NQO1_PONAB P05982, NQO1_RAT Q92PU3, NQOR1_RHIME
Q930L2, NQOR2_RHIME Q92Y27, NQOR3_RHIME A5G020, NQOR_ACICJ
B9M9X5, NQOR_ACIET B7J4K3, NQOR_ACIF2 B5EMU4, NQOR_ACIF5
B6JBZ6, NQOR_AFIC5 P58795, NQOR_AGRFC Q0A961, NQOR_ALKEH
O29904, NQOR_ARCFU Q5P5L5, NQOR_AROAE A8HRS7, NQOR_AZOC5
A1K9S9, NQOR_AZOSB C1DFX8, NQOR_AZOVD B2IEF8, NQOR_BEII9
Q89D74, NQOR_BRADU A5ECG6, NQOR_BRASB A4Z0W6, NQOR_BRASO
B2S5Q9, NQOR_BRUA1 Q2YQ23, NQOR_BRUA2 A6X0U8, NQOR_BRUA4
Q57D82, NQOR_BRUAB A9M560, NQOR_BRUC2 C0RJ23, NQOR_BRUMB
Q8YH68, NQOR_BRUME A5VQI8, NQOR_BRUO2 B0CGJ9, NQOR_BRUSI
Q8G0P0, NQOR_BRUSU B1Z3G9, NQOR_BURA4 A0KCF0, NQOR_BURCH
B4EPK7, NQOR_BURCJ Q0B2K2, NQOR_BURCM Q39LI8, NQOR_BURL3
A9AT43, NQOR_BURM1 B1KBY1, NQOR_BURO0 Q1BIC1, NQOR_BURO1
A4JT91, NQOR_BURVG B0SZC3, NQOR_CAUSK Q9AA17, NQOR_CAUVC
B8H1H5, NQOR_CAUVN Q11IN8, NQOR_CHESB Q1QYF4, NQOR_CHRSD
A8AI59, NQOR_CITK8 Q1LFW3, NQOR_CUPMC Q9RYU4, NQOR_DEIRA
A7ZKA9, NQOR_ECO24 B7UNY7, NQOR_ECO27 B7MIE9, NQOR_ECO45
B7LFB3, NQOR_ECO55 Q8X4B4, NQOR_ECO57 B5YU47, NQOR_ECO5E
B7NLC1, NQOR_ECO7I B7M8Y8, NQOR_ECO8A C4ZQD2, NQOR_ECOBW
B1X9C5, NQOR_ECODH A7ZYV7, NQOR_ECOHS A1A9Q9, NQOR_ECOK1
Q0TJ63, NQOR_ECOL5 P0A8G7, NQOR_ECOL6 B1IV93, NQOR_ECOLC
P0A8G6, NQOR_ECOLI B7N3F9, NQOR_ECOLU B6I980, NQOR_ECOSE
B1LJ00, NQOR_ECOSM Q1RDL3, NQOR_ECOUT A4W916, NQOR_ENT38
B7LP27, NQOR_ESCF3 B9M4V3, NQOR_GEODF Q39XL1, NQOR_GEOMG
Q74F05, NQOR_GEOSL A5G4G8, NQOR_GEOUR A9HFY5, NQOR_GLUDA
A1WUN2, NQOR_HALHL Q31GW8, NQOR_HYDCU B5XXP0, NQOR_KLEP3
A6W2V6, NQOR_MARMS A1U5D9, NQOR_MARN8 P58796, NQOR_METAC
Q46B88, NQOR_METBF B7KQ28, NQOR_METC4 A9VY95, NQOR_METEP
Q8PUV4, NQOR_METMA B1ZJX9, NQOR_METPB B1LY35, NQOR_METRJ
B0UFU2, NQOR_METS4 B8EMJ5, NQOR_METSB Q3J8H5, NQOR_NITOC
Q3SU01, NQOR_NITWN A1BAT3, NQOR_PARDP A7HVA3, NQOR_PARL1
B2JML0, NQOR_PARP8 B2T8L2, NQOR_PARPJ Q7N5I5, NQOR_PHOLL
Q9I509, NQOR_PSEAE Q1MHW6, NQOR_RHIJ3 B9JEB9, NQOR_RHIR8
A5VA47, NQOR_RHIWR B6ITN1, NQOR_RHOCS Q2IRH1, NQOR_RHOP2
Q07TR7, NQOR_RHOP5 Q6NBB9, NQOR_RHOPA Q21B81, NQOR_RHOPB
Q130C0, NQOR_RHOPS B3QFA1, NQOR_RHOPT Q2RXG7, NQOR_RHORT
B5F202, NQOR_SALA4 A9MH45, NQOR_SALAR B5FR47, NQOR_SALDC
B5R056, NQOR_SALEP B5R6H0, NQOR_SALG2 B4TEP2, NQOR_SALHS
B4T2V2, NQOR_SALNS Q5PG91, NQOR_SALPA A9N6R4, NQOR_SALPB
C0Q886, NQOR_SALPC B5BBG6, NQOR_SALPK B4TSN0, NQOR_SALSV
Q8Z7N9, NQOR_SALTI Q8ZQ40, NQOR_SALTY A8GCS6, NQOR_SERP5
Q32HQ6, NQOR_SHIDS Q0T630, NQOR_SHIF8 P0A8G8, NQOR_SHIFL
Q3Z3B7, NQOR_SHISS C3MCH2, NQOR_SINFN C4XGC2, NQOR_SOLM1
Q2LPM7, NQOR_SYNAS A0LNQ8, NQOR_SYNFM C4L7R5, NQOR_TOLAT
B3E9H6, NQOR_TRIL1 A7IE31, NQOR_XANP2 A1JMU2, NQOR_YERE8
A7FJ02, NQOR_YERP3 Q1C8L9, NQOR_YERPA B2K198, NQOR_YERPB
Q8ZF61, NQOR_YERPE A9R7R8, NQOR_YERPG Q1CHD6, NQOR_YERPN
A4TK49, NQOR_YERPP Q66BP3, NQOR_YERPS B1JNA9, NQOR_YERPY
Q9XBR5, NQOR_ZYMMO Q941Z0, NQR1_ORYSJ Q941Y8, NQR2_ORYSJ
Q9LK88, NQR_ARATH Q8H9D2, NQR_SOLTU A0A1D8PHR5, PST1_CANAL
Q59Y37, PST2_CANAL A0A1D8PT02, PST3_CANAL P39315, QOR2_ECOLI
Q8NJJ9, QOR_KLUMA Q9AYU0, QR2_TRIVS A0A1D8PT03, YCP4_CANAL

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-