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ENZYME

ENZYME entry: EC 1.7.3.3

Accepted Name
factor independent urate hydroxylase
Alternative Name(s)
urate oxidase
uric acid oxidase
uricase
uricase II
Reaction catalysed
H2O + O2 + urate <=> 5-hydroxyisourate + H2O2
Comment(s)
  • Was previously thought to be a copper protein, but it is now known that the enzymes from soybean (Glycine max), the mold Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion.
  • The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalyzed pathway in which EC 3.5.2.17 catalyzes the first step.
  • The enzyme is different from EC 1.14.13.113.
Cross-references
BRENDA 1.7.3.3
EC2PDB 1.7.3.3
ExplorEnz 1.7.3.3
PRIAM enzyme-specific profiles 1.7.3.3
KEGG Ligand Database for Enzyme Nomenclature 1.7.3.3
IUBMB Enzyme Nomenclature 1.7.3.3
IntEnz 1.7.3.3
MEDLINE Find literature relating to 1.7.3.3
MetaCyc 1.7.3.3
Rhea expert-curated reactions 1.7.3.3
UniProtKB/Swiss-Prot
Q45697, PUCL_BACSB O32141, PUCL_BACSU P34798, URIC1_CANLI
P04670, URIC1_SOYBN P34799, URIC2_CANLI O04104, URIC2_SOYBN
Q8MKJ2, URIC_AOTTR O04420, URIC_ARATH D0VWQ1, URIC_ARTGO
Q00511, URIC_ASPFL Q3MHG7, URIC_BOVIN Q5FZI9, URIC_CANLF
P78609, URIC_CYBJA Q6DG85, URIC_DANRE Q54LT2, URIC_DICDI
P16163, URIC_DROME P22673, URIC_DROPS O44111, URIC_DROSU
P23194, URIC_DROVI P33282, URIC_EMENI D8JBB7, URIC_HALJB
D4GPU7, URIC_HALVD Q8MHW6, URIC_MACFA Q8MKJ3, URIC_MACMU
P25688, URIC_MOUSE P25689, URIC_PAPHA P53763, URIC_PHAVU
P16164, URIC_PIG P82858, URIC_PUCRE P11645, URIC_RABIT
P09118, URIC_RAT O74409, URIC_SCHPO

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