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ENZYME

ENZYME entry: EC 1.8.5.3

Accepted Name
respiratory dimethylsulfoxide reductase
Alternative Name(s)
dimethylsulfoxide reductase
DMSO reductase
Reaction catalysed
a menaquinone + dimethyl sulfide + H2O <=> a menaquinol + dimethyl sulfoxide
Comment(s)
  • The enzyme participates in bacterial electron transfer pathways in which dimethylsulfoxide (DMSO) is the terminal electron acceptor.
  • It is composed of three subunits - DmsA contains a bis(guanylyl molybdopterin) cofactor and a [4Fe-4S] cluster, DmsB is an iron- sulfur protein, and DmsC is a transmembrane protein that anchors the enzyme and accepts electrons from the quinol pool.
  • The electrons are passed through DmsB to DmsA and on to DMSO.
  • The enzyme can also reduce pyridine-N-oxide and trimethylamine N-oxide to the corresponding amines with lower activity.
Cross-references
BRENDA 1.8.5.3
EC2PDB 1.8.5.3
ExplorEnz 1.8.5.3
PRIAM enzyme-specific profiles 1.8.5.3
KEGG Ligand Database for Enzyme Nomenclature 1.8.5.3
IUBMB Enzyme Nomenclature 1.8.5.3
IntEnz 1.8.5.3
MEDLINE Find literature relating to 1.8.5.3
MetaCyc 1.8.5.3
Rhea expert-curated reactions 1.8.5.3
UniProtKB/Swiss-Prot
P18775, DMSA_ECOLI P45004, DMSA_HAEIN Q9HR74, DMSA_HALSA
Q57366, DSTOR_CERSP Q52675, DSTOR_RHOCA

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