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ENZYME

ENZYME entry: EC 3.4.17.23

Accepted Name
angiotensin-converting enzyme 2
Alternative Name(s)
ACE2
angiotensin converting enzyme 2
angiotensin converting enzyme-2
Reaction catalysed
angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine
Comment(s)
  • A transmembrane glycoprotein with an extracellular catalytic domain.
  • Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates.
  • Catalytic efficiency is 400-fold higher with angiotensin II (1-8) as a substrate than with angiotensin I (1-10).
  • Angiotensin-converting enzyme 2 also efficiently hydrolyzes des- Arg(9)-bradykinin, but it does not hydrolyze bradykinin.
  • Belongs to peptidase family M2.
Cross-references
BRENDA 3.4.17.23
EC2PDB 3.4.17.23
ExplorEnz 3.4.17.23
PRIAM enzyme-specific profiles 3.4.17.23
KEGG Ligand Database for Enzyme Nomenclature 3.4.17.23
IUBMB Enzyme Nomenclature 3.4.17.23
IntEnz 3.4.17.23
MEDLINE Find literature relating to 3.4.17.23
MetaCyc 3.4.17.23
Rhea expert-curated reactions 3.4.17.23
UniProtKB/Swiss-Prot
Q58DD0, ACE2_BOVIN Q56H28, ACE2_FELCA Q9BYF1, ACE2_HUMAN
Q8R0I0, ACE2_MOUSE Q56NL1, ACE2_PAGLA Q5RFN1, ACE2_PONAB
Q5EGZ1, ACE2_RAT

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