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ENZYME

ENZYME entry: EC 3.4.21.26

Accepted Name
prolyl oligopeptidase
Alternative Name(s)
post-proline cleaving enzyme
post-proline endopeptidase
prolyl endopeptidase
Reaction catalysed
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides
Comment(s)
  • Found in vertebrates, plants and Flavobacterium.
  • Generally cytosolic, commonly activated by thiol compounds.
  • Belongs to peptidase family S9A.
  • Formerly EC 3.4.22.18.
Cross-references
BRENDA 3.4.21.26
EC2PDB 3.4.21.26
ExplorEnz 3.4.21.26
PRIAM enzyme-specific profiles 3.4.21.26
KEGG Ligand Database for Enzyme Nomenclature 3.4.21.26
IUBMB Enzyme Nomenclature 3.4.21.26
IntEnz 3.4.21.26
MEDLINE Find literature relating to 3.4.21.26
MetaCyc 3.4.21.26
Rhea expert-curated reactions 3.4.21.26
UniProtKB/Swiss-Prot
A0A4S8L6U5, DBIP_DENBC A0A1Q3EPF5, LEDP_LENED C0HLV2, NEPRN_NEPVE
P9WEN5, OPHP_OMPOL E2JFG1, POPA_AMABI H2E7Q7, POPA_GALM3
E2JFG2, POPB_AMABI H2E7Q8, POPB_GALM3 Q06903, PPCE_AERHY
Q9XTA2, PPCE_BOVIN Q86AS5, PPCE_DICDI P27028, PPCE_ELIME
P48147, PPCE_HUMAN Q9QUR6, PPCE_MOUSE P23687, PPCE_PIG
O70196, PPCE_RAT P27195, PPCF_ELIMR A5D7B7, SEPR_BOVIN
Q12884, SEPR_HUMAN P97321, SEPR_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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