ENZYME entry: EC 3.4.22.49

Accepted Name

separase

Alternative Name(s)

separin

Reaction catalysed

All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage

Comment(s)

In both Saccharomyces cerevisiae and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis.
S.cerevisiae separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19.
Belongs to peptidase family C50.

Cross-references

BRENDA

3.4.22.49

EC2PDB

3.4.22.49

ExplorEnz

3.4.22.49

PRIAM enzyme-specific profiles

3.4.22.49

KEGG Ligand Database for Enzyme Nomenclature

3.4.22.49

IUBMB Enzyme Nomenclature

3.4.22.49

IntEnz

3.4.22.49

MEDLINE

Find literature relating to 3.4.22.49

MetaCyc

3.4.22.49

Rhea expert-curated reactions

3.4.22.49

UniProtKB/Swiss-Prot

P33144, BIMB_EMENI	P18296, CUT1_SCHPO	Q5IBC5, ESP1_ARATH
Q03018, ESP1_YEAST	Q14674, ESPL1_HUMAN	P60330, ESPL1_MOUSE
G5ED39, SEP1_CAEEL

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