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ENZYME

ENZYME entry: EC 3.5.4.16

Accepted Name
GTP cyclohydrolase I
Reaction catalysed
GTP + H2O <=> 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)
Comment(s)
  • The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic.
  • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.
Cross-references
BRENDA 3.5.4.16
EC2PDB 3.5.4.16
ExplorEnz 3.5.4.16
PRIAM enzyme-specific profiles 3.5.4.16
KEGG Ligand Database for Enzyme Nomenclature 3.5.4.16
IUBMB Enzyme Nomenclature 3.5.4.16
IntEnz 3.5.4.16
MEDLINE Find literature relating to 3.5.4.16
MetaCyc 3.5.4.16
Rhea expert-curated reactions 3.5.4.16
UniProtKB/Swiss-Prot
Q9CGE3, FOLKE_LACLA Q8GJP4, FOLKE_LACLM Q8YLL1, GCH11_NOSS1
Q9HYG8, GCH11_PSEAE Q88LV4, GCH11_PSEPK Q887V1, GCH11_PSESM
Q8YN49, GCH12_NOSS1 Q9I351, GCH12_PSEAE Q88JY1, GCH12_PSEPK
Q884Q3, GCH12_PSESM A3DHH6, GCH1_ACET2 A3N0R3, GCH1_ACTP2
B3GXP9, GCH1_ACTP7 B0BPI8, GCH1_ACTPJ A0KIN6, GCH1_AERHH
A4SPE8, GCH1_AERS4 Q8UEK8, GCH1_AGRFC Q5E4E4, GCH1_ALIF1
B5FF36, GCH1_ALIFM B6EGN8, GCH1_ALISL Q0A939, GCH1_ALKEH
B9JWF1, GCH1_ALLAM O66603, GCH1_AQUAE Q9SFV7, GCH1_ARATH
A8HUG2, GCH1_AZOC5 C1DHG2, GCH1_AZOVD C3P598, GCH1_BACAA
C3L8S8, GCH1_BACAC A0RBW5, GCH1_BACAH Q81SW2, GCH1_BACAN
B7JGZ6, GCH1_BACC0 Q73AY4, GCH1_BACC1 B7IP89, GCH1_BACC2
C1EN08, GCH1_BACC3 B7HHR5, GCH1_BACC4 B7HL21, GCH1_BACC7
A7GN48, GCH1_BACCN B9IVN3, GCH1_BACCQ Q81FQ8, GCH1_BACCR
Q63DM1, GCH1_BACCZ Q5L925, GCH1_BACFN Q64P85, GCH1_BACFR
Q6HL44, GCH1_BACHK A9VMC0, GCH1_BACMK A8FEL2, GCH1_BACP2
P48063, GCH1_BACPU P19465, GCH1_BACSU Q8A0U0, GCH1_BACTN
A7Z630, GCH1_BACVZ A1USJ5, GCH1_BARBK Q6G3J8, GCH1_BARHE
Q6FZZ4, GCH1_BARQU Q1LT77, GCH1_BAUCH B2IBC4, GCH1_BEII9
B3DR12, GCH1_BIFLD Q8G3S1, GCH1_BIFLO Q7VRX3, GCH1_BLOFL
Q492J7, GCH1_BLOPB Q89IW2, GCH1_BRADU C0ZCC7, GCH1_BREBN
B2S5T0, GCH1_BRUA1 Q2YQ03, GCH1_BRUA2 A6X0X0, GCH1_BRUA4
Q57D61, GCH1_BRUAB A9M586, GCH1_BRUC2 C0RJ47, GCH1_BRUMB
Q8YH94, GCH1_BRUME A5VQL0, GCH1_BRUO2 B0CGM4, GCH1_BRUSI
Q8G0L4, GCH1_BRUSU Q8KA05, GCH1_BUCAP Q19980, GCH1_CAEEL
A8MC60, GCH1_CALMQ Q8R7N2, GCH1_CALS4 A7ZB36, GCH1_CAMC1
A7GW42, GCH1_CAMC5 A8FJZ5, GCH1_CAMJ8 A7H1R1, GCH1_CAMJD
P51594, GCH1_CAMJE A1VXS2, GCH1_CAMJJ Q5HWX4, GCH1_CAMJR
B9KDZ8, GCH1_CAMLR Q3ADI2, GCH1_CARHZ Q9AAY3, GCH1_CAUVC
Q11JM4, GCH1_CHESB P50141, GCH1_CHICK Q3ATN0, GCH1_CHLCH
A4SF37, GCH1_CHLPM Q8KEA8, GCH1_CHLTE Q1QV64, GCH1_CHRSD
Q7NYZ2, GCH1_CHRVO A8AE79, GCH1_CITK8 Q97D54, GCH1_CLOAB
A7FU67, GCH1_CLOB1 C3KVW3, GCH1_CLOB6 A6LWG6, GCH1_CLOB8
A5I231, GCH1_CLOBH C1FN26, GCH1_CLOBJ B1IL94, GCH1_CLOBK
A7GDP1, GCH1_CLOBL B1L1S1, GCH1_CLOBM Q18BW7, GCH1_CLOD6
B9E092, GCH1_CLOK1 A5N6S3, GCH1_CLOK5 A0Q2L7, GCH1_CLONN
Q0TRM0, GCH1_CLOP1 Q8XLM2, GCH1_CLOPE Q0STY9, GCH1_CLOPS
C3PJE8, GCH1_CORA7 Q8FMG3, GCH1_COREF A4QH94, GCH1_CORGB
Q8NM84, GCH1_CORGL A9KFF3, GCH1_COXBN A9NDB3, GCH1_COXBR
Q83DE3, GCH1_COXBU Q3Z782, GCH1_DEHM1 A5FQD3, GCH1_DEHMB
Q3ZYB5, GCH1_DEHMC Q9RYB4, GCH1_DEIRA A4J5D0, GCH1_DESRM
Q94465, GCH1_DICDI P48596, GCH1_DROME A7ZNX6, GCH1_ECO24
B7UFG9, GCH1_ECO27 B7MF66, GCH1_ECO45 B7LAH4, GCH1_ECO55
P0A6T7, GCH1_ECO57 B5YWU3, GCH1_ECO5E B7NMB8, GCH1_ECO7I
B7MXG6, GCH1_ECO81 B7M4Z9, GCH1_ECO8A C4ZU03, GCH1_ECOBW
B1X7P1, GCH1_ECODH A8A214, GCH1_ECOHS A1AD13, GCH1_ECOK1
Q0TFT7, GCH1_ECOL5 P0A6T6, GCH1_ECOL6 B1IYB6, GCH1_ECOLC
P0A6T5, GCH1_ECOLI B7NCI3, GCH1_ECOLU B6I8K3, GCH1_ECOSE
B1LKQ0, GCH1_ECOSM Q1R9R9, GCH1_ECOUT C5BCL9, GCH1_EDWI9
A4WCI8, GCH1_ENT38 Q82Z12, GCH1_ENTFA B2VII2, GCH1_ERWT9
B7LVB3, GCH1_ESCF3 P51597, GCH1_EUGGR B0S1R1, GCH1_FINM2
A5FHM7, GCH1_FLAJ1 Q8RH43, GCH1_FUSNN Q5KXT7, GCH1_GEOKA
C5D3E8, GCH1_GEOSW Q7NK98, GCH1_GLOVI Q7VM90, GCH1_HAEDU
Q4QKH4, GCH1_HAEI8 A5UC59, GCH1_HAEIE A5UEW4, GCH1_HAEIG
P43866, GCH1_HAEIN Q2SPJ2, GCH1_HAHCH Q9KCC7, GCH1_HALH5
C4K3L4, GCH1_HAMD5 Q17WX5, GCH1_HELAH Q7VFG4, GCH1_HELHP
B6JME9, GCH1_HELP2 B5Z7T2, GCH1_HELPG Q1CSU6, GCH1_HELPH
Q9ZKS2, GCH1_HELPJ B2UU76, GCH1_HELPS P56462, GCH1_HELPY
Q0I3F6, GCH1_HISS1 B0UUA9, GCH1_HISS2 P30793, GCH1_HUMAN
B4U640, GCH1_HYDS0 A2BL58, GCH1_HYPBU Q0BXB5, GCH1_HYPNA
A6SZ52, GCH1_JANMA B5XP57, GCH1_KLEP3 A6TBN8, GCH1_KLEP7
Q88ST4, GCH1_LACPL Q38WN0, GCH1_LATSS Q6ACQ1, GCH1_LEIXX
B0S8X8, GCH1_LEPBA Q04P36, GCH1_LEPBJ Q056J8, GCH1_LEPBL
B0SRX6, GCH1_LEPBP Q72LY8, GCH1_LEPIC Q8EYG1, GCH1_LEPIN
Q92A75, GCH1_LISIN C1KWN3, GCH1_LISMC Q71Y82, GCH1_LISMF
B8DBZ3, GCH1_LISMH Q8Y5X1, GCH1_LISMO A0AK45, GCH1_LISW6
B1HTA3, GCH1_LYSSC Q65TR0, GCH1_MANSM Q0AM02, GCH1_MARMM
Q607T5, GCH1_METCA B0U881, GCH1_METS4 Q05915, GCH1_MOUSE
P51598, GCH1_MUCPU A0QA85, GCH1_MYCA1 B1MGU9, GCH1_MYCA9
P64208, GCH1_MYCBO A1KPU4, GCH1_MYCBP C1AI67, GCH1_MYCBT
A4T5P2, GCH1_MYCGI B8ZU42, GCH1_MYCLB O69531, GCH1_MYCLE
B2HJ53, GCH1_MYCMM Q743Z2, GCH1_MYCPA A5U8T4, GCH1_MYCTA
P9WN56, GCH1_MYCTO P9WN57, GCH1_MYCTU A0PV57, GCH1_MYCUA
A1TG42, GCH1_MYCVP P51599, GCH1_NEUCR Q2Y6B3, GCH1_NITMU
B2J1L7, GCH1_NOSP7 P51596, GCH1_ONCMY O61573, GCH1_OSTOS
A6LFE8, GCH1_PARD8 P57865, GCH1_PASMU Q6D3N3, GCH1_PECAS
C6DEM6, GCH1_PECCP A5D2D8, GCH1_PELTS Q4FL89, GCH1_PELUB
C0QPU5, GCH1_PERMH Q7N6K7, GCH1_PHOLL Q6LQL4, GCH1_PHOPR
P51600, GCH1_PHYBL B2RIJ1, GCH1_PORG3 Q7MWI5, GCH1_PORGI
Q15YG1, GCH1_PSEA6 Q3IF89, GCH1_PSET1 Q8ZWW5, GCH1_PYRAE
B1YCT7, GCH1_PYRNV Q8XZK8, GCH1_RALN1 P22288, GCH1_RAT
Q98LQ6, GCH1_RHILO Q92QB4, GCH1_RHIME Q7UJJ7, GCH1_RHOBA
Q2IY20, GCH1_RHOP2 Q6N4E7, GCH1_RHOPA Q212N0, GCH1_RHOPB
Q134L7, GCH1_RHOPS B3QE25, GCH1_RHOPT C3PNA0, GCH1_RICAE
A8GN89, GCH1_RICAH A8GUB6, GCH1_RICB8 Q1RID0, GCH1_RICBR
Q92I93, GCH1_RICCN Q4ULX3, GCH1_RICFE A8F1F2, GCH1_RICM5
Q9ZDE8, GCH1_RICPR C4K2D8, GCH1_RICPU B0BXB8, GCH1_RICRO
A8GRW0, GCH1_RICRS Q68WZ4, GCH1_RICTY B8I184, GCH1_RUMCH
Q980E8, GCH1_SACS2 B5EYP3, GCH1_SALA4 A9MK63, GCH1_SALAR
Q57ME6, GCH1_SALCH B5FNJ7, GCH1_SALDC B5R163, GCH1_SALEP
B5RC32, GCH1_SALG2 B4TAL5, GCH1_SALHS B4SY26, GCH1_SALNS
Q5PE52, GCH1_SALPA A9N6K0, GCH1_SALPB C0Q0U7, GCH1_SALPC
B5BE43, GCH1_SALPK B4TNQ0, GCH1_SALSV P64210, GCH1_SALTI
P64209, GCH1_SALTY O13774, GCH1_SCHPO A8GC24, GCH1_SERP5
A1S2C7, GCH1_SHEAM B8E4J0, GCH1_SHEB2 A3CZJ1, GCH1_SHEB5
A6WIA1, GCH1_SHEB8 A9KXZ9, GCH1_SHEB9 Q12SG0, GCH1_SHEDO
A3QIQ4, GCH1_SHELP Q8E9L6, GCH1_SHEON A4Y2K7, GCH1_SHEPC
A0L1S4, GCH1_SHESA Q0HE51, GCH1_SHESM Q0HZU8, GCH1_SHESR
A1REU0, GCH1_SHESW B2TVT9, GCH1_SHIB3 Q31YW1, GCH1_SHIBS
Q32EN8, GCH1_SHIDS Q0T2X1, GCH1_SHIF8 P0A6T8, GCH1_SHIFL
Q3Z053, GCH1_SHISS C3MB45, GCH1_SINFN A6U8C2, GCH1_SINMW
Q2NUE3, GCH1_SODGM Q8VYU3, GCH1_SOLLC Q3K0Y1, GCH1_STRA1
Q8E549, GCH1_STRA3 Q8DZI5, GCH1_STRA5 Q82EE8, GCH1_STRAW
Q9X8I3, GCH1_STRCO A8AZD8, GCH1_STRGC B1VSG4, GCH1_STRGG
Q8DUG2, GCH1_STRMU P0C0C2, GCH1_STRP1 Q04MF9, GCH1_STRP2
P0DB30, GCH1_STRP3 B5E6W5, GCH1_STRP4 Q5XCA9, GCH1_STRP6
C1CB65, GCH1_STRP7 P0A3E9, GCH1_STRP8 A2REL9, GCH1_STRPG
B1I918, GCH1_STRPI B8ZL26, GCH1_STRPJ P51595, GCH1_STRPN
P0DB31, GCH1_STRPQ B2ISL9, GCH1_STRPS P0C0C1, GCH1_STRPY
B5XLE8, GCH1_STRPZ P59656, GCH1_STRR6 A4W1S9, GCH1_STRS2
A3CKF4, GCH1_STRSV A4VVH1, GCH1_STRSY Q5LYM8, GCH1_STRT1
Q5M391, GCH1_STRT2 C1CC81, GCH1_STRZJ C1CIH2, GCH1_STRZP
C1CPG4, GCH1_STRZT Q4J8S2, GCH1_SULAC C3MZ97, GCH1_SULIA
C4KIH5, GCH1_SULIK C3MR62, GCH1_SULIL C3MXF1, GCH1_SULIM
C3NGB7, GCH1_SULIN C3N7B7, GCH1_SULIY B2V9P4, GCH1_SULSY
Q971G9, GCH1_SULTO Q54769, GCH1_SYNE7 Q2JR69, GCH1_SYNJA
Q2JPT8, GCH1_SYNJB Q5N623, GCH1_SYNP6 Q55759, GCH1_SYNY3
C5BL73, GCH1_TERTT Q47KU5, GCH1_THEFY B0KCE5, GCH1_THEP3
B0K5C1, GCH1_THEPX Q8DJB8, GCH1_THEVB B5YJV0, GCH1_THEYD
C4LDE6, GCH1_TOLAT A7N6L2, GCH1_VIBC1 Q9KLX5, GCH1_VIBCH
Q87GZ6, GCH1_VIBPA Q8D6I7, GCH1_VIBVU Q7MDE5, GCH1_VIBVY
Q8D2N7, GCH1_WIGBR Q7M933, GCH1_WOLSU Q8PEP3, GCH1_XANAC
Q3BM80, GCH1_XANC5 Q8P3B0, GCH1_XANCP B2I4L2, GCH1_XYLF2
Q9PC02, GCH1_XYLFA B0U794, GCH1_XYLFM Q87D63, GCH1_XYLFT
P51601, GCH1_YEAST A1JU09, GCH1_YERE8 A7FJL1, GCH1_YERP3
B2JZ02, GCH1_YERPB Q8ZG15, GCH1_YERPE A9R1B1, GCH1_YERPG
B1JQJ4, GCH1_YERPY A0AYZ1, GCH41_BURCH Q39AS8, GCH41_BURL3
B1K3S8, GCH41_BURO0 Q1BR24, GCH41_BURO1 Q1LPE1, GCH41_CUPMC
Q47IT5, GCH41_DECAR A0B338, GCH42_BURCH Q393P5, GCH42_BURL3
B1K5N3, GCH42_BURO0 Q1BLY8, GCH42_BURO1 Q1LK35, GCH42_CUPMC
Q47BI9, GCH42_DECAR Q6FBI2, GCH4_ACIAD B2ULP4, GCH4_AKKM8
Q0VMK6, GCH4_ALCBS Q0AA39, GCH4_ALKEH Q5P229, GCH4_AROAE
A1K4Q9, GCH4_AZOSB C1DM03, GCH4_AZOVD Q65ML7, GCH4_BACLD
P94398, GCH4_BACSU Q6MKE9, GCH4_BDEBA Q2KZ16, GCH4_BORA1
Q7WL36, GCH4_BORBR Q7W7P9, GCH4_BORPA A9ITA7, GCH4_BORPD
Q7VV88, GCH4_BORPE B1Z1G3, GCH4_BURA4 Q0BAL7, GCH4_BURCM
A9ANA1, GCH4_BURM1 A3MBD3, GCH4_BURM7 A2S0N7, GCH4_BURM9
Q62DU0, GCH4_BURMA A1UYQ5, GCH4_BURMS A3P7W3, GCH4_BURP0
Q3JKA4, GCH4_BURP1 A3NMF5, GCH4_BURP6 Q63JF5, GCH4_BURPS
Q2T7N4, GCH4_BURTA A4JLT5, GCH4_BURVG B9MNP4, GCH4_CALBD
A4XG24, GCH4_CALS8 A3PH01, GCH4_CERS1 Q3J5D3, GCH4_CERS4
A4WQ81, GCH4_CERS5 B9KM22, GCH4_CERSK Q1R153, GCH4_CHRSD
B5EDQ6, GCH4_CITBB A8AF20, GCH4_CITK8 Q47VM6, GCH4_COLP3
B5Y6R9, GCH4_COPPD Q0K861, GCH4_CUPNH Q474C1, GCH4_CUPPJ
A9C020, GCH4_DELAS B8J1Q5, GCH4_DESDA A8ZUJ6, GCH4_DESOH
Q6AMT5, GCH4_DESPS Q727G3, GCH4_DESVH B8DLK8, GCH4_DESVM
A1VAN0, GCH4_DESVV A5EXB0, GCH4_DICNV B5YCT4, GCH4_DICT6
B8DZH0, GCH4_DICTD A8LS52, GCH4_DINSH B1YHT1, GCH4_EXIS2
C4KZ55, GCH4_EXISA A7HKP2, GCH4_FERNB Q39R36, GCH4_GEOMG
Q74FW8, GCH4_GEOSL C6E7E6, GCH4_GEOSM A5G8S1, GCH4_GEOUR
Q2SLC0, GCH4_HAHCH Q9KE60, GCH4_HALH5 A1WYI8, GCH4_HALHL
A4G1X0, GCH4_HERAR Q31EF8, GCH4_HYDCU Q5R041, GCH4_IDILO
A6SUS5, GCH4_JANMA Q28R88, GCH4_JANSC Q6U5S4, GCH4_KLEPN
C5CEC0, GCH4_KOSOT Q1MPD2, GCH4_LAWIP B9E8N6, GCH4_MACCJ
A0L8I1, GCH4_MAGMM C6C0U6, GCH4_MARSD Q605G6, GCH4_METCA
Q1GZD6, GCH4_METFK A2SJ45, GCH4_METPP Q5F9K6, GCH4_NEIG1
A9M3N5, GCH4_NEIM0 Q9JV35, GCH4_NEIMA Q9K023, GCH4_NEIMB
A1KT61, GCH4_NEIMF Q0AFY5, GCH4_NITEC Q82VD1, GCH4_NITEU
Q2YCH6, GCH4_NITMU Q3J9J7, GCH4_NITOC Q8EQK9, GCH4_OCEIH
Q30X45, GCH4_OLEA2 B1ZTR5, GCH4_OPITP A1BA17, GCH4_PARDP
B2JP67, GCH4_PARP8 Q13RX0, GCH4_PARXL A1AU47, GCH4_PELPD
A4SZK2, GCH4_POLAQ Q48HN1, GCH4_PSE14 Q15Z55, GCH4_PSEA6
A6VF17, GCH4_PSEA7 B7V776, GCH4_PSEA8 Q02DG9, GCH4_PSEAB
Q9HT35, GCH4_PSEAE Q1I2L2, GCH4_PSEE4 Q4K3E8, GCH4_PSEF5
C3K4H5, GCH4_PSEFS A8F7Q8, GCH4_PSELT A4Y119, GCH4_PSEMY
A5W348, GCH4_PSEP1 Q3K4B0, GCH4_PSEPF B0KR89, GCH4_PSEPG
Q88HM9, GCH4_PSEPK B1JFN3, GCH4_PSEPW Q882P7, GCH4_PSESM
Q3ILJ5, GCH4_PSET1 Q4ZU60, GCH4_PSEU2 A1STF0, GCH4_PSYIN
Q8XX96, GCH4_RALN1 Q168P4, GCH4_ROSDO Q5LTR1, GCH4_RUEPO
Q1GF96, GCH4_RUEST A1AVX5, GCH4_RUTMC A8GF39, GCH4_SERP5
A7WZ02, GCH4_STAA1 A6TZ43, GCH4_STAA2 Q2FJ74, GCH4_STAA3
Q2G0L1, GCH4_STAA8 A5IQC0, GCH4_STAA9 Q2YS98, GCH4_STAAB
Q5HIA9, GCH4_STAAC A6QEL9, GCH4_STAAE Q99W43, GCH4_STAAM
Q7A777, GCH4_STAAN Q6GJA3, GCH4_STAAR Q6GBS1, GCH4_STAAS
A8YZR4, GCH4_STAAT Q8NXX2, GCH4_STAAW B9DKT0, GCH4_STACT
Q5HRI1, GCH4_STAEQ Q8CTR6, GCH4_STAES Q4L3P5, GCH4_STAHJ
Q49VB3, GCH4_STAS1 Q2LUP0, GCH4_SYNAS Q3A091, GCH4_SYNC1
A0LQR3, GCH4_SYNFM B7ICT4, GCH4_THEAB A6LKE7, GCH4_THEM4
Q9WXP6, GCH4_THEMA B9K795, GCH4_THENN A5IL29, GCH4_THEP1
B1LAA9, GCH4_THESQ Q3SKF2, GCH4_THIDA A5CXA1, GCH4_VESOH
Q8PLL4, GCH4_XANAC Q3BUL9, GCH4_XANC5 Q4UTV2, GCH4_XANC8
B0RTU4, GCH4_XANCB Q8P9T3, GCH4_XANCP Q2P374, GCH4_XANOM
B2SJL4, GCH4_XANOP Q5H0A0, GCH4_XANOR B2IAI3, GCH4_XYLF2
Q9PBP4, GCH4_XYLFA B0U741, GCH4_XYLFM Q87DA5, GCH4_XYLFT
Q9ZKP2, GTPC1_HELPJ O25613, GTPC1_HELPY

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