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ENZYME

ENZYME entry: EC 5.4.2.2

Accepted Name
phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
Alternative Name(s)
glucose phosphomutase
phosphoglucose mutase
Reaction catalysed
alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate
Comment(s)
  • Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate.
  • This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization.
  • Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. cf. EC 5.4.2.5.
  • Formerly EC 2.7.5.1.
Cross-references
BRENDA 5.4.2.2
EC2PDB 5.4.2.2
ExplorEnz 5.4.2.2
PRIAM enzyme-specific profiles 5.4.2.2
KEGG Ligand Database for Enzyme Nomenclature 5.4.2.2
IUBMB Enzyme Nomenclature 5.4.2.2
IntEnz 5.4.2.2
MEDLINE Find literature relating to 5.4.2.2
MetaCyc 5.4.2.2
Rhea expert-curated reactions 5.4.2.2
UniProtKB/Swiss-Prot
Q02E40, ALGC_PSEAB P26276, ALGC_PSEAE Q88C93, ALGC_PSEPK
Q88BD4, ALGC_PSESM P18159, PGCA_BACSU Q2FE11, PGCA_STAA3
Q2FVC1, PGCA_STAA8 Q2YW66, PGCA_STAAB Q5HD61, PGCA_STAAC
Q99RE2, PGCA_STAAM Q7A3K7, PGCA_STAAN Q6GDU9, PGCA_STAAR
Q6G6I3, PGCA_STAAS Q8NUV4, PGCA_STAAW Q5HLD2, PGCA_STAEQ
Q8CN38, PGCA_STAES Q4L9R5, PGCA_STAHJ Q49WH7, PGCA_STAS1
Q08DP0, PGM1_BOVIN Q23919, PGM1_DICDI P36871, PGM1_HUMAN
Q4R5E4, PGM1_MACFA Q9D0F9, PGM1_MOUSE P47244, PGM1_PARTE
P00949, PGM1_RABIT P38652, PGM1_RAT P33401, PGM1_YEAST
Q54UQ2, PGM2_DICDI Q96G03, PGM2_HUMAN Q7TSV4, PGM2_MOUSE
O02606, PGM2_PARTE Q5RFI8, PGM2_PONAB P37012, PGM2_YEAST
O49299, PGMC1_ARATH P93804, PGMC1_MAIZE Q9SGC1, PGMC2_ARATH
P93805, PGMC2_MAIZE Q9SNX2, PGMC_BROIN P93262, PGMC_MESCR
Q9SM60, PGMC_PEA Q9ZSQ4, PGMC_POPTN Q9M4G4, PGMC_SOLTU
Q68BJ6, PGMMM_THEKO Q9SCY0, PGMP_ARATH Q9SMM0, PGMP_BRANA
Q9SM59, PGMP_PEA Q9M4G5, PGMP_SOLTU Q4WY53, PGM_ASPFU
P57749, PGM_ASPOR Q9VUY9, PGM_DROME P36938, PGM_ECOLI
Q9P931, PGM_EMENI O18719, PGM_ENTDI O15820, PGM_ENTH1
P38569, PGM_KOMXY P40390, PGM_NEIGO P57002, PGM_NEIMA
P40391, PGM_NEIMB P39671, PGM_RHIRD O74374, PGM_SCHPO
B0RVK5, XANA_XANCB P0C7J2, XANA_XANCP

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