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ENZYME

ENZYME entry: EC 6.2.1.3

Accepted Name
long-chain-fatty-acid--CoA ligase
Alternative Name(s)
acyl-activating enzyme
acyl-CoA synthetase
fatty acid thiokinase (long chain)
lignoceroyl-CoA synthase
Reaction catalysed
a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate
Comment(s)
  • Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.
  • The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
Cross-references
BRENDA 6.2.1.3
EC2PDB 6.2.1.3
ExplorEnz 6.2.1.3
PRIAM enzyme-specific profiles 6.2.1.3
KEGG Ligand Database for Enzyme Nomenclature 6.2.1.3
IUBMB Enzyme Nomenclature 6.2.1.3
IntEnz 6.2.1.3
MEDLINE Find literature relating to 6.2.1.3
MetaCyc 6.2.1.3
Rhea expert-curated reactions 6.2.1.3
UniProtKB/Swiss-Prot
Q2KHW5, ACBG1_BOVIN Q96GR2, ACBG1_HUMAN Q4R4P9, ACBG1_MACFA
Q99PU5, ACBG1_MOUSE Q924N5, ACBG1_RAT Q5ZKR7, ACBG2_CHICK
Q5FVE4, ACBG2_HUMAN Q2XU92, ACBG2_MOUSE A1L1K7, ACBG2_RAT
Q7ZYC4, ACBG2_XENLA Q9JID6, ACSL1_CAVPO P33121, ACSL1_HUMAN
P41216, ACSL1_MOUSE P18163, ACSL1_RAT O95573, ACSL3_HUMAN
Q9CZW4, ACSL3_MOUSE Q5R668, ACSL3_PONAB Q63151, ACSL3_RAT
O60488, ACSL4_HUMAN Q9QUJ7, ACSL4_MOUSE O35547, ACSL4_RAT
Q9ULC5, ACSL5_HUMAN Q8JZR0, ACSL5_MOUSE O88813, ACSL5_RAT
Q9UKU0, ACSL6_HUMAN Q91WC3, ACSL6_MOUSE P33124, ACSL6_RAT
Q9V3S9, BGM_DROME P9WQ36, FAC13_MYCTO P9WQ37, FAC13_MYCTU
Q7TYX8, FAC15_MYCBO B2HGV4, FAC15_MYCMM O53521, FAC15_MYCTU
Q7TWC5, FAC17_MYCBO B2HHZ8, FAC17_MYCMM O53551, FAC17_MYCTU
Q7TWB7, FAC19_MYCBO B2HI05, FAC19_MYCMM A0R4Q2, FAC19_MYCS2
P9WQ50, FAC19_MYCTO P9WQ51, FAC19_MYCTU O05307, FAC6_MYCTU
O06417, FAC8_MYCTU Q55DR6, FCSA_DICDI Q1ZXQ4, FCSB_DICDI
Q9V3U0, HMLL_DROME O22898, LACS1_ARATH Q9XIA9, LACS2_ARATH
Q9C7W4, LACS3_ARATH Q9T0A0, LACS4_ARATH Q9T009, LACS5_ARATH
Q8LPS1, LACS6_ARATH Q8LKS5, LACS7_ARATH Q9SJD4, LACS8_ARATH
Q9CAP8, LACS9_ARATH O60135, LCF1_SCHPO P30624, LCF1_YEAST
Q9P7D7, LCF2_SCHPO P39518, LCF2_YEAST P39002, LCF3_YEAST
P47912, LCF4_YEAST P94547, LCFA_BACSU Q8XDR6, LCFA_ECO57
P69452, LCFA_ECOL6 P69451, LCFA_ECOLI P46450, LCFA_HAEIN
P63522, LCFA_SALTI P63521, LCFA_SALTY Q8ZES9, LCFA_YERPE
O07610, LCFB_BACSU Q5SKN9, LCFCS_THET8 P44446, LCFH_HAEIN
Q3ZKN0, S27A1_BOVIN Q6PCB7, S27A1_HUMAN Q60714, S27A1_MOUSE
P97849, S27A1_RAT O14975, S27A2_HUMAN O35488, S27A2_MOUSE
P97524, S27A2_RAT Q5K4L6, S27A3_HUMAN O88561, S27A3_MOUSE
Q6P1M0, S27A4_HUMAN Q4R3Y4, S27A4_MACFA Q91VE0, S27A4_MOUSE
Q5RDY4, S27A4_PONAB Q9Y2P5, S27A5_HUMAN Q4LDG0, S27A5_MOUSE
Q9ES38, S27A5_RAT Q9Y2P4, S27A6_HUMAN E9Q9W4, S27A6_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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