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ENZYME

ENZYME entry: EC 6.2.1.43

Accepted Name
2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase
Reaction catalysed
2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate
Comment(s)
  • The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1- naphthoate moiety of the antibiotic neocarzinostatin.
  • In vitro the enzyme also catalyzes the activation of other 1-naphthoic acid analogs, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate.
Cross-references
BRENDA 6.2.1.43
EC2PDB 6.2.1.43
ExplorEnz 6.2.1.43
PRIAM enzyme-specific profiles 6.2.1.43
KEGG Ligand Database for Enzyme Nomenclature 6.2.1.43
IUBMB Enzyme Nomenclature 6.2.1.43
IntEnz 6.2.1.43
MEDLINE Find literature relating to 6.2.1.43
MetaCyc 6.2.1.43
Rhea expert-curated reactions 6.2.1.43
UniProtKB/Swiss-Prot
Q84HC5, NCSB2_STRCZ

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