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ENZYME

ENZYME entry: EC 6.2.1.49

Accepted Name
long-chain fatty acid adenylyltransferase FadD28
Reaction catalysed
a long-chain fatty acid + ATP + holo-[mycocerosate synthase] <=> AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]
Comment(s)
  • The enzyme, found in certain mycobacteria, activates long-chain fatty acids by adenylation and transfers them to EC 2.3.1.111.
  • The enzyme participates in the biosynthesis of the virulent lipids dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL).
  • Formerly EC 2.7.7.95.
Cross-references
BRENDA 6.2.1.49
EC2PDB 6.2.1.49
ExplorEnz 6.2.1.49
PRIAM enzyme-specific profiles 6.2.1.49
KEGG Ligand Database for Enzyme Nomenclature 6.2.1.49
IUBMB Enzyme Nomenclature 6.2.1.49
IntEnz 6.2.1.49
MEDLINE Find literature relating to 6.2.1.49
MetaCyc 6.2.1.49
Rhea expert-curated reactions 6.2.1.49
UniProtKB/Swiss-Prot
Q02278, FAA28_MYCBO B2HIM0, FAA28_MYCMM P9WQ58, FAA28_MYCTO
P9WQ59, FAA28_MYCTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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