Abstract
In order for the immune system to generate its vast numbers of receptors, B- and T-cell receptor genes are created by recombining preexisting gene segments. This well- coordinated set of reactions is explained
MeSH terms
- Animals
- DNA Repair
- DNA-Binding Proteins
- Evolution, Molecular
- Gene Rearrangement
- Humans
- Immune System / physiology*
- Mice
- Mice, SCID
- Mice, Transgenic
- Models, Biological
- Nuclear Proteins
- Nucleic Acid Conformation
- Receptors, Antigen, B-Cell / physiology*
- Receptors, Antigen, T-Cell / physiology*
- Recombination, Genetic
- Translocation, Genetic
- VDJ Recombinases / metabolism
- VDJ Recombinases / physiology*
Substances
- DNA-Binding Proteins
- Nuclear Proteins
- Receptors, Antigen, B-Cell
- Receptors, Antigen, T-Cell
- VDJ Recombinases