Abstract
The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.
MeSH terms
- Anemia / etiology*
- Animals
- Antimicrobial Cationic Peptides / biosynthesis*
- Cells, Cultured
- Cytokines / metabolism*
- Hepatocytes / metabolism
- Hepcidins
- Humans
- Inflammation / complications
- Inflammation / metabolism*
- Interleukin-6 / metabolism*
- Interleukin-6 / pharmacology
- Intestinal Mucosa / metabolism
- Iron / metabolism
- Macrophages / metabolism
- Mice
- Models, Biological
Substances
- Antimicrobial Cationic Peptides
- Cytokines
- HAMP protein, human
- Hamp protein, mouse
- Hepcidins
- Interleukin-6
- Iron