Abstract
Chromosomal translocations involving immunoglobulin switch regions are commonly thought to arise from aberrant AID-induced DNA lesions. New data, however, suggest AID does not initiate such lesions, but acts subsequently in the B cell transformation process.
MeSH terms
- Animals
- Antibodies / genetics
- Cytidine Deaminase
- Cytosine Deaminase / metabolism
- DNA Glycosylases / genetics
- DNA Glycosylases / metabolism
- Genes, myc*
- Humans
- Immunoglobulin Class Switching / genetics*
- Immunoglobulin Class Switching / physiology
- Mutation
- Receptors, Antigen, B-Cell / genetics
- Translocation, Genetic* / physiology
- Uracil-DNA Glycosidase
Substances
- Antibodies
- Receptors, Antigen, B-Cell
- DNA Glycosylases
- Uracil-DNA Glycosidase
- AICDA (activation-induced cytidine deaminase)
- Cytosine Deaminase
- Cytidine Deaminase