The GGA proteins: key players in protein sorting at the trans-Golgi network

Eur J Cell Biol. 2004 Jul;83(6):257-62. doi: 10.1078/0171-9335-00374.

Abstract

The GGA (Golgi-localized, gamma-ear containing, ADP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.

Publication types

  • Review

MeSH terms

  • ADP-Ribosylation Factors / genetics
  • ADP-Ribosylation Factors / metabolism*
  • Adaptor Proteins, Vesicular Transport / genetics
  • Adaptor Proteins, Vesicular Transport / metabolism*
  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Endosomes / metabolism
  • Golgi Apparatus / metabolism*
  • Humans
  • Molecular Structure
  • Protein Structure, Tertiary
  • Protein Transport / physiology*
  • Receptor, IGF Type 2 / metabolism
  • trans-Golgi Network / metabolism*

Substances

  • Adaptor Proteins, Vesicular Transport
  • Carrier Proteins
  • GGA adaptor proteins
  • Receptor, IGF Type 2
  • ADP-Ribosylation Factors