Abstract
The GGA (Golgi-localized, gamma-ear containing, ADP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.
MeSH terms
- ADP-Ribosylation Factors / genetics
- ADP-Ribosylation Factors / metabolism*
- Adaptor Proteins, Vesicular Transport / genetics
- Adaptor Proteins, Vesicular Transport / metabolism*
- Animals
- Carrier Proteins / genetics
- Carrier Proteins / metabolism*
- Endosomes / metabolism
- Golgi Apparatus / metabolism*
- Humans
- Molecular Structure
- Protein Structure, Tertiary
- Protein Transport / physiology*
- Receptor, IGF Type 2 / metabolism
- trans-Golgi Network / metabolism*
Substances
- Adaptor Proteins, Vesicular Transport
- Carrier Proteins
- GGA adaptor proteins
- Receptor, IGF Type 2
- ADP-Ribosylation Factors