Cellular iron: ferroportin is the only way out

Cell Metab. 2005 Mar;1(3):155-7. doi: 10.1016/j.cmet.2005.02.005.

Abstract

Ferroportin is the sole cellular efflux channel for iron and is regulated by the iron regulatory hormone hepcidin, which binds ferroportin and induces its internalization and degradation. New studies of ferroportin knockout mice define a key role for this transporter in physiological iron balance.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / metabolism
  • Antimicrobial Cationic Peptides / physiology
  • Cation Transport Proteins / metabolism*
  • Hepcidins
  • Homeostasis
  • Humans
  • Iron / metabolism*

Substances

  • Antimicrobial Cationic Peptides
  • Cation Transport Proteins
  • HAMP protein, human
  • Hamp protein, mouse
  • Hepcidins
  • metal transporting protein 1
  • Iron