Good ACE, bad ACE do battle in lung injury, SARS

Nat Med. 2005 Aug;11(8):821-2. doi: 10.1038/nm0805-821.

Abstract

Two studies show how the enzyme ACE2 protects against lung injury caused by SARS and other agents. ACE2 seems to counteract the effects of ACE, which are more damaging ( pages 875–879 ).

Publication types

  • News
  • Comment

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Animals
  • Carboxypeptidases / metabolism*
  • Down-Regulation
  • Mice
  • Peptidyl-Dipeptidase A / metabolism
  • Pulmonary Alveoli / metabolism*
  • Respiratory Distress Syndrome / enzymology*
  • Respiratory Distress Syndrome / etiology
  • Severe Acute Respiratory Syndrome / complications
  • Severe Acute Respiratory Syndrome / enzymology*
  • Severe acute respiratory syndrome-related coronavirus / metabolism*

Substances

  • Carboxypeptidases
  • Peptidyl-Dipeptidase A
  • Ace2 protein, mouse
  • Angiotensin-Converting Enzyme 2