Abstract
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Adenosine Triphosphate / isolation & purification*
- Chromatography, High Pressure Liquid
- Escherichia coli / growth & development
- Escherichia coli / metabolism*
- Molecular Conformation
- Spectrometry, Mass, Electrospray Ionization
- Tandem Mass Spectrometry
- Thiamine Triphosphate / isolation & purification*
Substances
- adenosine thiamine triphosphate
- Thiamine Triphosphate
- Adenosine Triphosphate
Associated data
- PubChem-Substance/22387977
- PubChem-Substance/22387978
- PubChem-Substance/22387979
- PubChem-Substance/22387980
- PubChem-Substance/22387981
- PubChem-Substance/22387982
- PubChem-Substance/22387983
- PubChem-Substance/22387984
- PubChem-Substance/22387985
- PubChem-Substance/22387986
- PubChem-Substance/22387987
- PubChem-Substance/22387988
- PubChem-Substance/22387989
- PubChem-Substance/22387990
- PubChem-Substance/22387991