RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection

Antimicrob Agents Chemother. 2007 Dec;51(12):4518-20. doi: 10.1128/AAC.00808-07. Epub 2007 Sep 17.

Abstract

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Biofilms / drug effects*
  • Biofilms / growth & development
  • Disease Models, Animal
  • Female
  • Peptides / pharmacology*
  • RNA, Bacterial / antagonists & inhibitors*
  • Rats
  • Rats, Wistar
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / prevention & control
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / growth & development
  • Stents / microbiology*
  • Teicoplanin / pharmacology
  • Ureter / surgery

Substances

  • Anti-Bacterial Agents
  • Peptides
  • RNA, Bacterial
  • RNAIII, Staphylococcus aureus
  • Teicoplanin