Wikis are part of the suite of Web 2.0 technologies enhancing collaboration and communication. This article describes the ways in which one academic health sciences library has utilized wiki software. The Eccles Health Sciences Library has found wikis to be valuable collaboration tools. Case scenarios and software selection recommendations will be outlined. Examples of collaborations using wikis include grant writing, strategic planning, departmental documentation, and committee work. Comparisons are made between externally hosted and locally hosted wiki software.