Curative pelvic exenteration for recurrent cervical carcinoma in the era of concurrent chemotherapy and radiation therapy. A systematic review

H Sardain; V Lavoue; M Redpath; N Bertheuil; F Foucher; J Levêque

doi:10.1016/j.ejso.2015.03.235

Curative pelvic exenteration for recurrent cervical carcinoma in the era of concurrent chemotherapy and radiation therapy. A systematic review

Eur J Surg Oncol. 2015 Aug;41(8):975-85. doi: 10.1016/j.ejso.2015.03.235. Epub 2015 Apr 14.

Authors

H Sardain¹, V Lavoue², M Redpath³, N Bertheuil⁴, F Foucher⁵, J Levêque⁶

Affiliations

¹ CHU de Rennes, Gynecology Department, Tertiary Surgery Center, Teaching Hospital of Rennes, Hôpital Sud, 16, Bd de Bulgarie, 35000 Rennes, France; Université de Rennes, Faculty of Medicine, 2 Henry Guilloux, 35000 Rennes, France.
² CHU de Rennes, Gynecology Department, Tertiary Surgery Center, Teaching Hospital of Rennes, Hôpital Sud, 16, Bd de Bulgarie, 35000 Rennes, France; Université de Rennes, Faculty of Medicine, 2 Henry Guilloux, 35000 Rennes, France; INSERM, ER440, Oncogenesis, Stress and Signaling (OSS), Rennes, France. Electronic address: Vincent.lavoue@chu-rennes.fr.
³ McGill University, Department of Pathology, Jewish General Hospital, Côte Sainte Catherine, Montreal, QC, Canada.
⁴ Université de Rennes, Faculty of Medicine, 2 Henry Guilloux, 35000 Rennes, France; CHU de Rennes, Department of Plastic, Reconstructive and Aesthetic Surgery, Tertiary Surgery Center, Teaching Hospital of Rennes, Hôpital Sud, 16, Bd de Bulgarie, 35000 Rennes, France.
⁵ CHU de Rennes, Gynecology Department, Tertiary Surgery Center, Teaching Hospital of Rennes, Hôpital Sud, 16, Bd de Bulgarie, 35000 Rennes, France.
⁶ CHU de Rennes, Gynecology Department, Tertiary Surgery Center, Teaching Hospital of Rennes, Hôpital Sud, 16, Bd de Bulgarie, 35000 Rennes, France; Université de Rennes, Faculty of Medicine, 2 Henry Guilloux, 35000 Rennes, France; INSERM, ER440, Oncogenesis, Stress and Signaling (OSS), Rennes, France.

PMID: 25922209
DOI: 10.1016/j.ejso.2015.03.235

Abstract

Objective: Pelvic exenteration requires complete resection of the tumor with negative margins to be considered a curative surgery. The purpose of this review is to assess the optimal preoperative evaluation and surgical approach in patients with recurrent cervical cancer to increase the chances of achieving a curative surgery with decreased morbidity and mortality in the era of concurrent chemoradiotherapy.

Methods: Review of English publications pertaining to cervical cancer within the last 25 years were included using PubMed and Cochrane Library searches.

Results: Modern imaging (MRI and PET-CT) does not accurately identify local extension of microscopic disease and is inadequate for preoperative planning of extent of resection. Today, only half of pelvic exenteration procedures obtain uninvolved surgical margins.

Conclusion: Clear margins are required for curative pelvic exenterations, but are poorly predictable by pre-operative assessment. More extensive surgery, i.e. the infra-elevator exenteration with vulvectomy, is a logical surgical choice to increase the rate of clear margins and to improve patient survival following surgery for recurrent cervical carcinoma.

Keywords: Cervical carcinoma; Pelvic exenteration; Recurrence.

Publication types

Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Chemoradiotherapy
Female
Humans
Neoplasm Recurrence, Local / therapy*
Pelvic Exenteration / methods*
Uterine Cervical Neoplasms / therapy*