TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

Li Wen Shen; Hui Juan Mao; Yan Ling Wu; Yoshimasa Tanaka; Wen Zhang

doi:10.1016/j.biochi.2017.07.016

TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

Biochimie. 2017 Nov:142:1-10. doi: 10.1016/j.biochi.2017.07.016. Epub 2017 Aug 1.

Authors

Li Wen Shen¹, Hui Juan Mao¹, Yan Ling Wu², Yoshimasa Tanaka³, Wen Zhang⁴

Affiliations

¹ Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
² Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China. Electronic address: ylwu@cdc.zj.cn.
³ Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
⁴ Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China. Electronic address: wzhang63@zjut.edu.cn.

Abstract

Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2.

Keywords: Coronavirus; Influenza virus; TMPRSS2; Therapeutics.

Publication types

Review

MeSH terms

Animals
Coronavirus Infections / drug therapy*
Coronavirus Infections / enzymology*
Humans
Influenza, Human / drug therapy*
Influenza, Human / enzymology*
Molecular Targeted Therapy / methods*
Serine Endopeptidases / metabolism*
Virus Replication / drug effects

Substances

Serine Endopeptidases