Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2
Tracking and tracing SARS-CoV-2 mutations
Abstract
INTRODUCTION
RESULTS
Genomic epidemiology reconstruction of SARS-CoV-2 infection clusters in Austria
Dynamics of low-frequency and fixed mutations in clusters
Impact of transmission bottlenecks and intrahost evolution on SARS-CoV-2 mutational dynamics
DISCUSSION
MATERIALS AND METHODS
Study design
Sample collection and processing
Sample sequencing
Sequencing data processing and analysis
Epidemiological analyses and identification of SARS-CoV-2 infection clusters
Phylogenetic analysis and inference of transmission lines
Bottleneck estimation
Intrapatient time series analyses
Genetic distance
Statistical methods
Acknowledgments
Supplementary Material
Summary
Resources
REFERENCES AND NOTES
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December 2020
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- Alexandra Popa et al.
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