Fire-Diffuse-Fire Model of Dynamics of Intracellular Calcium Waves
Abstract
When Ca2+ is released from internal stores in living cells, the resulting wave of increased concentration can travel without deformation (continuous propagation) or with burst-like behavior (saltatory propagation). We analyze the "fire-diffuse-fire" model in order to illuminate the differences between these two modes of propagation. We show that the Ca2+ release wave in immature Xenopus oocytes and cardiac myocytes is saltatory, whereas the fertilization wave in the mature oocyte is continuous.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- May 1999
- DOI:
- 10.1073/pnas.96.11.6060
- Bibcode:
- 1999PNAS...96.6060D