Protein Ontology

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NOTICE: The PRO ID format has changed from PRO: to PR: (e.g. PRO:000000563 will become PR:000000563) effective with this release (16.0). The previous format will be maintained until release 17.0, and can be found in the alternative PRO source files downloadable at ftp://ftp.pir.georgetown.edu/databases/ontology/pro_obo/old_format and on the alternative PRO web site http://pir.georgetown.edu/pro/pro_old.shtml.

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(NIH grant #R01 GM080646-01)

PRO is a formal representation of protein objects, providing both descriptions of these objects and the relationships between them (current release: 16).

Example: methylated (sample output)

Retrieve a PRO entry (enter a PRO ID):

Example: PR:000000563 (sample output)

Search PRO (enter text or ID):

Example: smad (sample output)

Annotation:

RACE-PRO

PRO tracker

PRO encompasses a sub-ontology of proteins based on evolutionary relatedness (ProEvo) and a sub-ontology of the multiple protein forms produced from a given gene (ProForm). PRO is interoperable with other OBO Foundry ontologies--such as the Sequence Ontology (SO) and the Gene Ontology (GO)--that provide representations of protein qualities. This interoperability facilitates cross-species comparisons, pathway analysis, disease modeling, and the generation of new hypotheses through data integration and machine reasoning.

(Explanation of the figure)

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