National Toxicology Program

The RoC is an informational scientific and public health document first ordered by Congress in 1978 that identifies and discusses agents, substances, mixtures, or exposure circumstances that may pose a hazard to human health by virtue of their carcinogenicity. The RoC is published biennially and serves as a meaningful and useful compilation of data on:

1. The carcinogenicity (ability to cause cancer), genotoxicity (ability to damage genes), and biologic mechanisms (modes of action in the body) of the listed substance in humans and/or animals.
2. The potential for human exposure to these substances.
3. Federal regulations to limit exposures.

For more background information please select Questions & Answers about the RoC.

View the most recent edition of the RoC (11^th) on-line or download a copy as a zipped file (30 mb).  

Note: Correction in Asbestos Substance Profile (posted February 13, 2009)

View the review process for the 12^th RoC.