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RosettaAntibody: antibody modeling server for prediction of antibody Fv structures. The antibody homology modeling server is built on the Rosetta structure prediction suite comprising of knowledge-based techniques for template selection, grafting for non-H3 CDR loops, de novo loop modeling for creating CDR-H3, and docking to optimize the relative orientation of the light and heavy chains. Click on "submit" on the left to request a prediction job, or click on "queue" to view all jobs.

The antigen binding surface of the ten top-scoring antibody homology models, generated by the RosettaAntibody antibody modeling server, superposed on the antibody crystal structure for D3H44 Fab (PDB ID: 1JPT). The native conformation is colored yellow-green and the structure closest to the native is colored salmon. Side chains are shown for the native and the structure closest to the native that contact the antigen in the co-crystal structure