KEGG     ENZYME: 3.4.17.23
Entry
EC 3.4.17.23                Enzyme                                 
Name
angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:R09535]
Reaction(KEGG)
R09535
Substrate
angiotensin II [CPD:C02135];
H2O [CPD:C00001]
Product
angiotensin-(1--7);
L-phenylalanine [CPD:C00079]
Comment
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.
History
EC 3.4.17.23 created 2009
Orthology
K09708   angiotensin-converting enzyme 2
Genes
HSA 59272(ACE2)
PTR 465511(ACE2)
PPS 100970340(ACE2)
GGO 101142534(ACE2)
PON 100171441(ACE2)
NLE 100602708(ACE2)
HMH 116811532(ACE2)
MCC 712790(ACE2)
MCF 102130864(ACE2)
MTHB 126946901
MNI 105478157(ACE2)
CSAB 103231639(ACE2)
CATY 105574684(ACE2)
PANU 101008749(ACE2)
TGE 112615413(ACE2)
MLEU 105550583(ACE2)
RRO 104664530(ACE2)
RBB 108539696(ACE2)
TFN 117077264(ACE2)
PTEH 111531712(ACE2)
CANG 105510462
CJC 100408882(ACE2)
SBQ 101045190(ACE2)
CIMI 108291904(ACE2)
CSYR 103267011(ACE2)
MMUR 105882317(ACE2)
LCAT 123628560(ACE2)
PCOQ 105805773(ACE2)
OGA 100951881(ACE2)
MMU 70008(Ace2)
MCAL 110286854(Ace2)
MPAH 110313851(Ace2)
RNO 302668(Ace2)
MCOC 116090418(Ace2)
ANU 117695200(Ace2)
MUN 110542541(Ace2)
CGE 100772552(Ace2)
MAUA 101823817(Ace2)
PROB 127218185(Ace2)
PLEU 114705723(Ace2)
MORG 121439480(Ace2)
MFOT 126512736
AAMP 119804711(Ace2)
NGI 103740288(Ace2)
HGL 101697829(Ace2)
CPOC 100302675(Ace2)
DORD 105997641(Ace2)
DSP 122108549(Ace2)
PLOP 125344172(Ace2)
NCAR 124971823
MMMA 107144246(Ace2)
OCU 100327258(ACE2)
OPI 101526767(ACE2)
TUP 102484728(ACE2)
GVR 103607293
CFA 480847(ACE2)
CLUD 112653200(ACE2)
VVP 112910549(ACE2)
VLG 121483384(ACE2)
NPO 129518830(ACE2)
AML 100465802(ACE2)
UMR 103668146(ACE2)
UAH 113240702(ACE2)
UAR 123797272(ACE2)
ELK 111157129
LLV 125091709
MPUF 101673097(ACE2)
MNP 132006914(ACE2)
MLK 131821656(ACE2)
NVS 122897655(ACE2)
ORO 101373514(ACE2)
EJU 114218071(ACE2)
ZCA 113931501(ACE2)
MLX 118004949(ACE2)
NSU 110572485(ACE2)
LWW 102726269
FCA 554349(ACE2)
PYU 121025614(ACE2)
PCOO 112871621(ACE2)
PBG 122476826(ACE2)
LRUF 124509367
PTG 102965716(ACE2)
PPAD 109248320(ACE2)
PUC 125931501
AJU 106974224
HHV 120232915(ACE2)
BTA 509235(ACE2)
BOM 102274886(ACE2)
BIU 109555348(ACE2)
BBUB 102409199(ACE2)
BBIS 104984774(ACE2)
CHX 102184608(ACE2)
OAS 101103622(ACE2)
BTAX 128070268(ACE2)
ODA 120882560(ACE2)
CCAD 122434819(ACE2)
MBEZ 129564307(ACE2)
SSC 100144303(ACE2)
CFR 102523304(ACE2)
CBAI 105079297(ACE2)
CDK 105100402(ACE2)
VPC 102526063(ACE2)
BACU 103009000(ACE2)
LVE 103086585(ACE2)
OOR 101283738(ACE2)
DLE 111168887(ACE2)
PCAD 102996907(ACE2)
PSIU 116747656(ACE2)
NASI 112399149(ACE2)
ECB 100055952(ACE2)
EPZ 103568003(ACE2)
EAI 106841569(ACE2)
MYB 102259026(ACE2)
MYD 102763166(ACE2)
MMYO 118654484(ACE2)
MLF 102419076(ACE2)
MNA 107529512(ACE2)
PKL 118719785(ACE2)
EFUS 103298184(ACE2)
HAI 109395939(ACE2)
DRO 112313373(ACE2)
SHON 118987251(ACE2)
AJM 119058376(ACE2)
PDIC 114504693(ACE2)
PHAS 123829997(ACE2)
MMF 118636490(ACE2)
RFQ 117022979(ACE2)
PPAM 129076971(ACE2)
PALE 102888407(ACE2)
PGIG 120611083(ACE2)
PVP 105294000(ACE2)
RAY 107497263(ACE2)
MJV 108390919(ACE2)
TOD 119246786(ACE2)
SARA 101538370(ACE2)
LAV 100663153(ACE2)
TMU 101343545
ETF 101656395(ACE2)
DNM 101429092(ACE2)
MDO 100031783(ACE2)
GAS 123241705(ACE2)
SHR 100917420(ACE2)
AFZ 127553615
PCW 110222490(ACE2)
OAA 100085223(ACE2)
GGA 418623(ACE2)
PCOC 116230727(ACE2)
MGP 100541186(ACE2)
CJO 107325566(ACE2)
TPAI 128076552(ACE2)
LMUT 125687963(ACE2)
NMEL 110392736(ACE2)
APLA 101792697(ACE2)
ACYG 106037784(ACE2)
CATA 118245768(ACE2)
AFUL 116498237(ACE2)
TGU 100232752(ACE2)
LSR 110471619(ACE2)
SCAN 103815821(ACE2)
PMOA 120504620(ACE2)
OTC 121342248(ACE2)
PRUF 121356213(ACE2)
GFR 102037445(ACE2)
FAB 101814772(ACE2)
OMA 130252717(ACE2)
PHI 102108306(ACE2)
PMAJ 107206020(ACE2)
CCAE 111922841(ACE2)
CCW 104686166(ACE2)
CBRC 103611746(ACE2)
ETL 114066567(ACE2)
ZAB 102067801(ACE2)
ACHL 103810970(ACE2)
SVG 106852915(ACE2)
MMEA 130578770(ACE2)
HRT 120748819(ACE2)
FPG 101911905(ACE2)
FCH 102045810(ACE2)
CLV 102095592(ACE2)
EGZ 104127303(ACE2)
NNI 104022575(ACE2)
PCRI 104029332(ACE2)
PLET 104624367(ACE2)
EHS 104502443(ACE2)
PCAO 104049988(ACE2)
ACUN 113480767(ACE2)
TALA 104364304(ACE2)
PADL 103918227(ACE2)
AFOR 103896937(ACE2)
ACHC 115334679(ACE2)
HALD 104310355(ACE2)
HLE 104840548(ACE2)
AGEN 126052875
GCL 127026027
CCRI 104165694(ACE2)
CSTI 104561893(ACE2)
CMAC 104481125(ACE2)
MUI 104537500(ACE2)
BREG 104636426
FGA 104075932(ACE2)
GSTE 104261683(ACE2)
LDI 104350299(ACE2)
MNB 103771950(ACE2)
OHA 104334989(ACE2)
NNT 104405453(ACE2)
SHAB 115604077(ACE2)
PGUU 104470941(ACE2)
ACAR 104527265(ACE2)
CPEA 104385382(ACE2)
AVIT 104273417(ACE2)
CVF 104289986(ACE2)
RTD 128915154(ACE2)
CUCA 104063399(ACE2)
TEO 104374083(ACE2)
BRHI 104495535(ACE2)
AAM 106490772(ACE2)
AROW 112976192(ACE2)
NPD 112943996(ACE2)
TGT 104572141(ACE2)
DNE 112995661(ACE2)
SCAM 104140442(ACE2)
ASN 102388701(ACE2)
AMJ 102570994(ACE2)
CPOO 109306030(ACE2)
GGN 109303314(ACE2)
PSS 102452742(ACE2)
CMY 102938941(ACE2)
CCAY 125641506(ACE2)
DCC 119843507(ACE2)
CPIC 101950848(ACE2)
TST 117869503(ACE2)
CABI 116821846(ACE2)
MRV 120375732(ACE2)
ACS 100565298(ace2)
ASAO 132771692(ACE2)
PVT 110075460(ACE2)
SUND 121925094(ACE2)
PBI 103068164(ACE2)
PMUR 107290068(ACE2)
CTIG 120306512(ACE2)
TSR 106541239 106553039(ACE2)
PGUT 117675857(ACE2)
APRI 131199951(ACE2)
PTEX 113445202(ACE2)
NSS 113416856(ACE2)
VKO 123033092(ACE2)
PRAF 128413188(ACE2)
ZVI 118085306(ACE2)
HCG 128351280(ACE2)
GJA 107115822(ACE2)
STOW 125431331(ACE2)
EMC 129325501(ACE2)
XLA 100037182(ace2.S) 108707435(ace2.L)
XTR 100486137(ace2)
NPR 108792313(ACE2)
RTEM 120927763(ACE2)
BBUF 120994623(ACE2)
BGAR 122927935 122930372(ACE2)
MUO 115469546(ACE2)
GSH 117363038(ACE2)
DRE 492331(ace2)
SRX 107737258 107751135
SANH 107691301(ace2) 107695051
SGH 107555905 107569674
CCAR 109101192 109101497
CAUA 113055292 113111073(ace2)
CGIB 127968584 128022223
PTET 122354480(ace2)
LROH 127172960(ace2)
OMC 131549029(ace2)
PPRM 120480577(ace2)
RKG 130085545(ace2)
MAMB 125256625(ace2)
CIDE 127522319
MASI 127426183 127428003
TROS 130571431(ace2)
TDW 130410350(ace2)
MANU 129427964(ace2)
IPU 108259124
IFU 128603044(ace2)
PHYP 113547458(ace2)
SMEO 124380062(ace2)
TFD 113657143(ace2)
TVC 132838731(ace2)
AMEX 103030208(ace2)
CMAO 118800932(ace2)
EEE 113578258(ace2)
CHAR 105893318(ace2) 105893961
TRU 101066589(ace2)
TFS 130517506(ace2)
TNG GSTEN00018041G001
LCO 104919764(ace2)
NCC 104963551(ace2)
TBEN 117471608(ace2)
CGOB 115005777(ace2)
PGEO 117465461(ace2)
GACU 117549374(ace2)
ELY 117263329(ace2)
EFO 125878828(ace2)
PLEP 121945388(ace2)
SLUC 116054689(ace2)
ECRA 117947475(ace2)
ESP 116669656(ace2)
PFLV 114560278(ace2)
GAT 120808741(ace2)
PPUG 119225508(ace2)
AFB 129106465(ace2)
CLUM 117727424(ace2)
MSAM 119890262(ace2)
SCHU 122874501(ace2)
CUD 121521168(ace2)
ALAT 119018333(ace2)
MZE 101480744(ace2)
ONL 100699386(ace2)
OAU 116311736(ace2)
OML 112160389(ace2)
XMA 102218691(ace2)
XCO 114143639(ace2)
XHE 116719116(ace2)
PRET 103462028(ace2)
PFOR 103143561(ace2)
PLAI 106952008(ace2)
PMEI 106914635(ace2)
GAF 122820294(ace2)
PPRL 129369427(ace2)
CVG 107082518(ace2)
CTUL 119782330(ace2)
GMU 124867441(ace2)
NFU 107381688(ace2)
KMR 108250149(ace2)
ALIM 106536269(ace2)
NWH 119429166(ace2)
AOCE 111567340(ace2)
MCEP 125005739(ace2)
CSEM 103378664(ace2)
POV 109624773(ace2)
SSEN 122771881(ace2)
HHIP 117759282(ace2)
HSP 118113077(ace2)
LCF 108887946
SDU 111224725(ace2)
SLAL 111651666(ace2)
XGL 120794742(ace2)
HCQ 109526010(ace2)
SSCV 125966797
SBIA 133497730(ace2)
PEE 133399314(ace2)
PTAO 133467595(ace2)
BPEC 110161222(ace2)
MALB 109965722(ace2)
BSPL 114851880(ace2)
SJO 128360392(ace2)
SASA 106595857 106609069(ace2)
STRU 115188686 115188791
OTW 112239661(ace2)
OMY 110496986 110500299
OGO 124028887
OKI 109879259 109887010
OKE 118382156(ace2)
SALP 112076415(ace2)
SNH 120042338 120042431(ace2)
CCLU 121562841(ace2)
ELS 105019921(ace2)
SFM 108920456(ace2)
PKI 111850234(ace2)
AANG 118213842(ace2)
LOC 102690232(ace2)
PSPA 121320626(ace2) 121328027
ARUT 117406081 117407347(ace2)
PSEX 120523603(ace2)
LCM 102362771(ACE2)
CMK 103177482(ace2)
RTP 109912326
HOC 132820893(ace2)
LERI 129702785(ace2)
PMRN 116957162(ACE2)
BBEL 109476928
LPIC 129274227 129275092
AJC 117106339
SKO 100375272 100375575 102806594
OBB 114878034
CGIG 122405136
SOC 105205666
MPHA 105827808
HST 105186217
DQU 106744847
LHU 105672116
OBO 105281396
DPX DAPPUDRAFT_65345
DMK 116922098 116928362
DPZ 124312323 124328503 124328504 124340502
HAME 121875276
CQD 128692655
TCF 131883002
 ยป show all
Reference
1  [PMID:11815627]
  Authors
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P
  Title
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related  carboxypeptidase.
  Journal
J Biol Chem 277:14838-43 (2002)
DOI:10.1074/jbc.M200581200
  Sequence
[hsa:59272]
Reference
2  [PMID:17897633]
  Authors
Lambert DW, Hooper NM, Turner AJ
  Title
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
  Journal
Biochem Pharmacol 75:781-6 (2008)
DOI:10.1016/j.bcp.2007.08.012
Reference
3  [PMID:14754895]
  Authors
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW
  Title
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
  Journal
J Biol Chem 279:17996-8007 (2004)
DOI:10.1074/jbc.M311191200
Other DBs
ExplorEnz - The Enzyme Database:  3.4.17.23
IUBMB Enzyme Nomenclature:  3.4.17.23
ExPASy - ENZYME nomenclature database:  3.4.17.23
BRENDA, the Enzyme Database:  3.4.17.23

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