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Medical Microbiology begins with a review of the immune system, focusing on the body's response to invading microorganisms. Bacteria are then covered, first with a series of chapters presenting the general concepts of bacterial microbiology and then with chapters detailing the major bacterial pathogenes of humans. Similar sections cover virology, mycology, and parasitology. In each section, the introductory chapters stress the mechanisms of infection characteristic of that type of microorganism, thus providing the reader with a framework for understanding rather than memorizing the clinical behavior of the pathogens. The final section of the book Introduction to Infectious Diseases, is arranged by organ system and provides transition for clinical considerations.
Contents
- Co-Editors
- Authors
- Preface
- Chapter 1. Immunology Overview
Armond S. Goldman and Bellur S. Prabhakar.
- General Concepts
- Evolution of the Immune System
- Organization/Components/Functions
- Molecular Communications in the Immune System
- Cells of the Immune System
- Immunoglobulin Supergene Family
- Recognition of Self and Immune Tolerance
- The Complement System
- Defense against Infections
- Diseases Due to Immune Responses to Infectious Agents
- Ontogeny of Immunity
- Maternal Immunologic Agents Transferred to the Recipient Infant
- Immune Deficiencies
- References
- Section 1. Bacteriology
- Introduction to Bacteriology
- Chapter 2. Structure
Milton R.J. Salton and Kwang-Shin Kim.
- Chapter 3. Classification
Ellen Jo Baron.
- General Concepts
- Introduction
- Definitions
- Approaches to Taxonomy
- Phenotypic Characteristics Useful in Classification and Identification
- Classification Below and Above the Species Level
- Designation of New Species and Nomenclatural Changes
- Assessing Newly Described Bacteria
- Role of the Clinical Laboratory
- Interfacing with Public Health Laboratories
- Hazards of Clinical Laboratory Work
- References
- Chapter 4. Bacterial Metabolism
Peter Jurtshuk, Jr.
- Chapter 5. Genetics
Randall K. Holmes and Michael G. Jobling.
- Chapter 6. Normal Flora
Charles Patrick Davis.
- Chapter 7. Bacterial Pathogenesis
Johnny W. Peterson.
- Chapter 8. Specific Acquired Immunity
John B. Robbins, Rachel Schneerson, and Shousun C. Szu.
- Chapter 9. Epidemiology
Philip S. Brachman.
- Chapter 10. Principles of Diagnosis
John A. Washington.
- Chapter 11. Antimicrobial Chemotherapy
Harold C. Neu and Thomas D. Gootz.
- General Concepts
- Introduction
- Biochemical Basis of Antimicrobial Action
- Inhibition of Bacterial Cell Wall Synthesis
- Antibiotics that Affect the Function of Cytoplasmic Membranes
- Antibiotics that Inhibit Nucleic Acid Synthesis
- Antimicrobial Inhibitors of Ribosome Function
- Drugs that Inhibit Other Biochemical Targets
- Antibacterial Agents that Affect Mycobacteria
- Bacterial Resistance
- Combinations of Antimicrobial Agents
- Toxicology of Antimicrobial Agents
- Mechanism to Reduce Bacterial Resistance
- References
- Chapter 12. Staphylococcus
Timothy Foster.
- General Concepts
- Introduction
- Taxonomy
- Identification of Staphylococci in the Clinical laboratory
- Epidemiology of Staphylococcus Aureus Infections
- Clinical Manifestations of S Aureus
- Pathogenesis of S Aureus Infections
- Adherence
- Avoidance of Host Defenses
- Damage to the Host
- Other Extracellular Proteins
- Enzymes
- Coagulase Negative Staphylococci
- Resistance of Staphylococci to Antimicrobial Drugs
- Future Prospects
- References
- Chapter 13. Streptococcus
Maria Jevitz Patterson.
- Chapter 14. Neisseria, Moraxella, Kingella and Eikenella
Stephen A. Morse.
- Chapter 15. Bacillus
Peter C. B. Turnbull.
- Chapter 16. Miscellaneous Pathogenic Bacteria
Herbert Hof.
- Chapter 17. Anaerobes: General Characteristics
David J. Hentges.
- Chapter 18. Clostridia: Sporeforming Anaerobic Bacilli
Carol L. Wells and Tracy D. Wilkins.
- General Concepts
- Introduction
- Gas Gangrene and Related Clostridial Wound Infections
- Tetanus and Clostribium Tetani
- Botulism and Clostridium Botulinum
- Antibiotic-Associated Diarrhea, Pseudomembranous Colitis, and Clostridium Difficile
- Other Pathogenic Clostridia Food Poisoning and Clostridium perfringens
- References
- Chapter 19. Anaerobic Cocci
Carol L. Wells and Tracy D. Wilkins.
- Chapter 20. Anaerobic Gram-Negative Bacilli
Sydney M. Finegold.
- Chapter 21. Salmonella
Ralph A. Giannella.
- Chapter 22. Shigella
Thomas L. Hale and Gerald T. Keusch.
- Chapter 23. Campylobacter and Helicobacter
Guillermo I. Perez-Perez and Martin J. Blaser.
- Chapter 24. Cholera, Vibrio cholerae O1 and O139, and Other Pathogenic Vibrios
Richard A. Finkelstein.
- Chapter 25. Escherichia Coli in Diarrheal Disease
Doyle J. Evans, Jr. and Dolores G. Evans.
- Chapter 26. Escherichia, Klebsiella, Enterobacter, Serratia, Citrobacter, and Proteus
M. Neal Guentzel.
- Chapter 27. Pseudomonas
Barbara H. Iglewski.
- Chapter 28. Brucella
G.G. Alton and J.R.L. Forsyth.
- Chapter 29. Pasteurella, Yersinia, and Francisella
Frank M. Collins.
- Chapter 30. Haemophilus Species
Daniel M. Musher.
- Chapter 31. Bordetella
Horst Finger and Carl Heinz Wirsing von Koenig.
- Chapter 32. Corynebacterium Diphtheriae
John R. Murphy.
- Chapter 33. Mycobacteria and Nocardia
David N. McMurray.
- Chapter 34. Actinomyces, Propionibacterium propionicus, and Streptomyces
Geroge H.W. Bowden.
- Chapter 35. Leptospira
Russell C. Johnson.
- Chapter 36. Treponema
Justin D. Radolf.
- Chapter 37. Mycoplasmas
Shmuel Razin.
- Chapter 38. Rickettsiae
David H. Walker.
- Chapter 39. Chlamydia
Yechiel Becker.
- Chapter 40. Legionella
Washington C. Winn, Jr.
- Section 2. Virology
- Introduction to Virology
- Chapter 41. Structure and Classification of Viruses
Hans R. Gelderblom.
- Chapter 42. Multiplication
Bernard Roizman.
- General Concepts
- Initiation of Infection
- The Strategies of Viral Multiplication
- Single-stranded RNA viruses
- Double-stranded RNA viruses
- DNA virus genomes
- Viruses differ with respect to their assembly, maturation and egress from infected cells
- Variability in Viral Genomes and Viral Multiplication
- References
- Chapter 43. Viral Genetics
W. Robert Fleischmann, Jr.
- Chapter 44. Effects on Cells
Thomas Albrecht, Michael Fons, Istvan Boldogh, and Alan S. Rabson.
- Chapter 45. Viral Pathogenesis
Samuel Baron, Michael Fons, and Thomas Albrecht.
- Chapter 46. Persistent Viral Infections
Istvan Boldogh, Thomas Albrecht, and David D. Porter.
- Chapter 47. Tumor Viruses
Joan C. M. Macnab and David Onions.
- Chapter 48. Epidemiology and Evolution
Frank Fenner.
- Chapter 49. Nonspecific Defenses
Ferdinando Dianzani and Samuel Baron.
- Chapter 50. Immune Defenses
Gary R. Klimpel.
- Chapter 51. Control of Viral Infections and Diseases
Karen L. Goldenthal, Karen Midthun, and Kathryn C. Zoon.
- Chapter 52. Chemotherapy of Viral Infections
Erik De Clercq.
- Chapter 53. Picornaviruses
Marguerite Yin-Murphy and Jeffrey W. Almond.
- Chapter 54. Alphaviruses (Togaviridae) and Flaviviruses (Flaviviridae)
Alan L. Schmaljohn and David McClain.
- Chapter 55. Togaviruses: Rubella Virus
Paul D. Parkman.
- Chapter 56. Bunyaviruses
Robert E. Shope.
- Chapter 57. Arenaviruses
Charles J. Pfau.
- Chapter 58. Orthomyxoviruses
Robert B. Couch.
- Chapter 59. Paramyxoviruses
Gisela Enders.
- Chapter 60. Coronaviruses
David A.J. Tyrrell and Steven H. Myint.
- Chapter 61. Rhabdoviruses: Rabies Virus
Charles E. Rupprecht.
- Chapter 62. Human Retroviruses
Miles W. Cloyd.
- Chapter 63. Rotaviruses, Reoviruses, Coltiviruses, and Orbiviruses
Albert Z. Kapikian and Robert E. Shope.
- Chapter 64. Parvoviruses
John R. Pattison and Gary Patou.
- Chapter 65. Norwalk Virus and Other Caliciviruses
Neil R. Blacklow.
- Chapter 66. Papovaviruses
Janet S. Butel.
- Chapter 67. Adenoviruses
Walter Doerfler.
- Chapter 68. Herpesviruses
Richard J. Whitley.
- General Concepts
- Introduction
- General Biologic Properties
- Structure
- Classification
- Replication and Latency
- Diagnosis
- Herpes Simplex Viruses
- Varicella-Zoster Virus
- Cytomegalovirus
- Epstein-Barr Virus
- Human Herpesvirus 6 and 7
- Kaposi's Sarcoma Herpesvirus
- B-Virus
- Control of Herpesvirus Infection
- References
- Chapter 69. Poxviruses
Derrick Baxby.
- Chapter 70. Hepatitis Viruses
Arie J. Zuckerman.
- Chapter 71. Subacute Spongiform Unconventional Virus Encephalopathies
Clarence J. Gibbs and David M. Asher.
- Chapter 72. Filoviruses
Heinz Feldmann and Hans-Dieter Klenk.
- Section 3. Mycology
- Introduction to Mycology
- General Concepts of Mycology
Michael R. McGinnis and Stephen K. Tyring.
- Introduction to Mycology
Michael R. McGinnis and Stephen K. Tyring.
- Chapter 73. Basic Biology of Fungi
Garry T. Cole.
- Chapter 74. Disease Mechanisms of Fungi
George S. Kobayashi.
- Chapter 75. Spectrum of Mycoses
Thomas J. Walsh and Dennis M. Dixon.
- Chapter 76. Antifungal Agents
Dennis M. Dixon and Thomas J. Walsh.
- Section 4. Parasitology
- Introduction to Parasitology
- Chapter 77. Protozoa: Structure, Classification, Growth, and Development
Robert G. Yaeger.
- Chapter 78. Protozoa: Pathogenesis and Defenses
John Richard Seed.
- Chapter 79. Intestinal Protozoa: Amebas
William A. Sodeman, Jr.
- Chapter 80. Other Intestinal Protozoa and Trichomonas Vaginalis
Ernest A. Meyer.
- Chapter 81. Free-Living Amebas: Naegleria, Acanthamoeba and Balamuthia
Augusto Julio Martinez.
- Chapter 82. Hemoflagellates
Rodrigo A. Zeledón.
- Chapter 83. Malaria
James M. Crutcher and Stephen L. Hoffman.
- Chapter 84. Toxoplasma Gondii
J. P. Dubey.
- Chapter 85. Pneumocystis Carinii
Walter T. Hughes.
- Chapter 86. Helminths: Structure, Classification, Growth, and Development
Gilbert A. Castro.
- Chapter 87. Helminths: Pathogenesis and Defenses
Derek Wakelin.
- Chapter 88. Schistosomes and Other Trematodes
Barbara L. Doughty.
- Chapter 89. Cestodes
Donald Heyneman.
- General Concepts
- Introduction
- Taenia saginata, The Beef Tapeworm
- Taenia solium, The Pork Tapeworm
- Taenia multiceps, The Coenurus Tapeworm
- Echinococcus granulosus, The Hydatid Tapeworm
- Echinococcus multilocularis, The Multiloculate or Alveolar Hydatid Tapeworm
- Hymenolepis nana, The Dwarf Tapeworm
- Hymenolepis diminuta, The Rat Tapeworm
- Dipylidium caninum, The Double-Pored Tapeworm
- Diphyllobothrium latum, The Broad Fish Tapeworm
- References
- Chapter 90. Enteric Nematodes of Humans
John H. Cross.
- Chapter 91. Enteric Nematodes of Lower Animals Transmitted to Humans: Zoonoses
Doris S. Kelsey.
- Chapter 92. Filarial Nematodes
John H. Cross.
- Section 5. Introduction to Infectious Diseases
- Introduction to Infectious Diseases
- Chapter 93. Infections of the Respiratory System
Purushothama V. Dasaraju and Chien Liu.
- Chapter 94. Microbiology of the Circulatory System
Lawrence L. Pelletier, Jr.
- Chapter 95. Microbiology of the Gastrointestinal Tract
Sherwood L. Gorbach.
- Chapter 96. Microbiology of the Nervous System
Richard T. Johnson.
- Chapter 97. Microbiology of the Genitourinary System
Allan Ross Ronald and Michelle J. Alfa.
- Chapter 98. Microbial Infections of Skin and Nails
Raza Aly.
- Chapter 99. Microbiology of Dental Decay and Periodontal Disease
Walter J. Loesche.
- Chapter 100. Bone, Joint, and Necrotizing Soft Tissue Infections
Jon T. Mader and Jason Calhoun.
Accurate indications, adverse reactions, and dosage schedules for drugs are provided in this book, but it is possible that they may change. The reader is urged to review the package information data of the manufacturers of the medications mentioned.
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