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    Tmprss2 transmembrane protease, serine 2 [ Mus musculus (house mouse) ]

    Gene ID: 50528, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tmprss2provided by MGI
    Official Full Name
    transmembrane protease, serine 2provided by MGI
    Primary source
    MGI:MGI:1354381
    See related
    Ensembl:ENSMUSG00000000385 AllianceGenome:MGI:1354381
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D16Ertd61e
    Summary
    Predicted to enable scavenger receptor activity and serine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; liver and biliary system; and respiratory system. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 149.8), colon adult (RPKM 109.6) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C4; 16 57.53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97365882..97460741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97564682..97659541, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene STARR-seq mESC enhancer starr_41630 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41631 Neighboring gene STARR-seq mESC enhancer starr_41632 Neighboring gene MX dynamin-like GTPase 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:97814757-97815058 Neighboring gene STARR-seq mESC enhancer starr_41635 Neighboring gene predicted gene, 41512 Neighboring gene predicted gene, 41513

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection. Metzdorf K, et al. Viruses, 2023 Jan 18. PMID 36851486, Free PMC Article
    2. Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions. Li X, et al. Nat Commun, 2022 Jul 26. PMID 35882856, Free PMC Article
    3. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2. Vo T, et al. Sci Rep, 2022 Jan 25. PMID 35079032, Free PMC Article
    4. H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice. Lambertz RLO, et al. Virol J, 2020 Apr 22. PMID 32321537, Free PMC Article
    5. Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis. Lambertz RLO, et al. J Gen Virol, 2019 Jul. PMID 31099738

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport.
      Title: Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport.
    2. Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion.
      Title: Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion.
    3. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection.
      Title: TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection.
    4. Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways.
      Title: Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways.
    5. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.
      Title: Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.
    6. Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury.
      Title: Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury.
    7. EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
      Title: EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
    8. Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.
      Title: Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.
    9. Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung.
      Title: Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung.
    10. Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19.
      Title: Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (10)  1 citation
    • Endonuclease-mediated (10) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6821

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 
    Process Evidence Code Pubs
    involved_in positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		 
    involved_in protein autoprocessing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
    		 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 

    General protein information

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    Preferred Names
    transmembrane protease serine 2
    Names
    epitheliasin
    plasmic transmembrane protein X
    NP_056590.2
    XP_006523127.1
    XP_006523128.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015775.2 → NP_056590.2  transmembrane protease serine 2

      See identical proteins and their annotated locations for NP_056590.2

      Status: PROVISIONAL

      Source sequence(s)
      BC054348
      Consensus CDS
      CCDS37417.1
      UniProtKB/Swiss-Prot
      Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
      UniProtKB/TrEMBL
      Q3UKE3
      Related
      ENSMUSP00000000395.7, ENSMUST00000000395.8
      Conserved Domains (3) summary
      cd00112
      Location:112 → 147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254 → 485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152 → 247
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      97365882..97460741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523064.3 → XP_006523127.1  transmembrane protease serine 2 isoform X1

      See identical proteins and their annotated locations for XP_006523127.1

      UniProtKB/Swiss-Prot
      Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
      UniProtKB/TrEMBL
      Q3UKE3
      Conserved Domains (3) summary
      cd00112
      Location:112 → 147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254 → 485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152 → 247
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. XM_006523065.2 → XP_006523128.1  transmembrane protease serine 2 isoform X1

      See identical proteins and their annotated locations for XP_006523128.1

      UniProtKB/Swiss-Prot
      Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
      UniProtKB/TrEMBL
      Q3UKE3
      Conserved Domains (3) summary
      cd00112
      Location:112 → 147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254 → 485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152 → 247
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIQ8.3 GenPept UniProtKB/Swiss-Prot:Q9JIQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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