Clinical immunology : principles and practice
Robert R. Rich (Editor)
"Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate today's latest knowledge and evidence-based practices that result in improved patient care. This trusted resource features sweeping content updates, rewritten chapters, a highly clinical perspective, and an easy-to-use organization designed to enhance your diagnosis and management skills in daily practice"--Publisher's description
Internet Resources
1 online resource (xviii, 1318 pages) : illustrations (chiefly color)
9780702070396, 9780702068966, 0702070394, 0702068969
1023865227
Section 1: Principles of immune response. The human immune response
Organization of the immune system
Innate immunity
Antigen receptor genes, gene products, and co-receptors
The major histocompatibility complex
Antigens and antigen presentation
B-cell development and differentiation
T-cell development
Cytokines and cytokine receptors
Chemokines and chemokine receptors
Lymphocyte adhesion and trafficking
T-cell activation and tolerance
Regulated cell death
The microbiota in immunity and inflammation
Section 2: Host defense mechanisms and inflammation. Immunoglobulin function
Helper T-cell subsets and control of the inflammatory response
Cytotoxic T lymphocytes and natural killer cells
Regulatory immune cells
Host defenses in the skin
Host defenses at mucosal surfaces
Complement in host deficiencies and diseases
Phagocyte deficiencies
Mast cells, basophils, and mastocytosis
Eosinophils and eosinophilia
Section 3: Host defenses to infectious agents. Host defenses to viruses
Host defenses to intracellular bacteria
Host defenses to extracellular bacteria
Host defenses to spirochetes
Host defenses to fungi
Host defenses to protozoa
Host defenses to helminths
Section 4: Immunologic deficiencies. Approach to the evaluation of the immunodeficient patient
Human genomics in immunology
Primary antibody deficiencies
Primary T-cell immunodeficiencies
Immunodeficiencies at the interface of innate and adaptive immunity
Infections in the immunocompromised host
Immune deficiencies at the extremes of age
HIV infection and acquired immunodeficiency syndrome
Autoantibody mediated phenocopies of primary immunodeficiency diseases
Section 5: Allergic diseases. Immunological mechanisms of airway diseases and pathways to therapy
Urticaria, angioedema, and anaphylaxis
Allergic reactions to stinging and biting insects
Atopic and contact dermatitis
Food allergy
Eosinophil-associated gastrointestinal disorders
Allergic disorders of the eye
Drug hypersensitivity
Occupational respiratory allergies
Section 6: Systemic immune diseases. Mechanisms of autoimmunity
Systemic lupus erythematosus
Rheumatoid arthritis
Juvenile idiopathic arthritis
Sjögren's syndrome
Scleroderma-systemic sclerosis
Inflammatory muscle diseases
Spondyloarthritis
Small and medium vessel primary vasculitis
Large-vessel vasculitides
Systemic autoinflammatory syndromes
Antiphospholipid syndrome
Section 7: Organ-specific inflammatory disease. Immunohematologic disorders
Bullous diseases of the skin and mucous membranes
Immunology of psoriasis
Myasthenia gravis
Multiple sclerosis
Autoimmune peripheral neuropathies
Immunologic renal diseases
Inflammation and atherothrombosis
Autoimmune thyroid diseases
Diabetes and related autoimmune diseases
Immunologic lung diseases
Sarcoidosis
Immunologic ocular disease
Immunologic diseases of the gastrointestinal tract
Inflammatory hepatobiliary diseases
Section 8: Immunology of neoplasia. Tumor immunotherapy
Lymphoid leukemias
Lymphomas
Monoclonal gammopathies
Section 9: Transplantation. Concepts and challenges in organ transplantation: rejection, immunosuppression, and tolerance
Immune reconstitution therapy for immunodeficiency
Hematopoietic stem cell transplantation for malignant diseases
Section 10: Prevention and therapy of immunologic diseases. Immunoglobulin therapy: replacement and immunomodulation
Gene therapy
Glucocorticoids
Immunomodulating pharmaceuticals
Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders
Biological modifiers of inflammation
Vaccines
Immunotherapy of allergic disease
Section 11: Diagnostic immunology. Flow cytometry
Assessment of functional immune responses
Assessment of neutrophil function
Assessment of human allergic diseases
Molecular methods
Appendices. Selected CD molecules and their characteristics
Laboratory reference values
Vaccine schedules
"Expert consult."
Revised edition of: Clinical immunology : principles and practice / Robert R. Rich [and others]. 4th ed. ©2013