Aging, sex, and DNA repair
Discusses the universality of the problem of DNA damage, and meiosis as an adaptation for DNA repair. The authors describe ageing as a consequence of accumulated DNA damage, and explore mating, in eukaryotes, as an mdaptation for masking mutation.
xii, 382 pages : illustrations ; 24 cm
9780120928606, 0120928604
22542921
Major ideas and historical perspectives; DNA damage; immediate consequences of DNA damage; accumulation of DNA damage hypothesis of ageing applied to mammals; oxidative DNA damage as a potential major cause of ageing; additional evidence bearing on the DNA damage hypothesis of ageing; ageing in non-vertebrates with comparisons to aspects of ageing in mammals; DNA repair with emphasis on single-strand damages; DNA repair with emphasis on recombinational repair; meiosis and meiotic recombination; meiosis viewed as an adaptation for DNA repair; the selective advantage of outcrossing ; evolutionary aspects of sex; other theories of ageing and sex; overview - future directions, and implications.