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Scarless wound healing: Transitioning from fetal research to regenerative healing
Alessandra L. Moore,
Clement D. Marshall,
Leandra A. Barnes,
Matthew P. Murphy,
Ryan C. Ransom,
Michael T. Longaker,
Alessandra L. Moore
Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorClement D. Marshall
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorLeandra A. Barnes
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorMatthew P. Murphy
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorRyan C. Ransom
Department of Surgery, Stanford University School of Medicine, Stanford, California
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California
Search for more papers by this authorCorresponding Author
Michael T. Longaker
Department of Surgery, Stanford University School of Medicine, Stanford, California
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California
Correspondence
Michael T. Longaker, Department of Surgery, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305. Email: [email protected]
Search for more papers by this author
Alessandra L. Moore,
Clement D. Marshall,
Leandra A. Barnes,
Matthew P. Murphy,
Ryan C. Ransom,
Michael T. Longaker,
Alessandra L. Moore
Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorClement D. Marshall
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorLeandra A. Barnes
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorMatthew P. Murphy
Department of Surgery, Stanford University School of Medicine, Stanford, California
Search for more papers by this authorRyan C. Ransom
Department of Surgery, Stanford University School of Medicine, Stanford, California
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California
Search for more papers by this authorCorresponding Author
Michael T. Longaker
Department of Surgery, Stanford University School of Medicine, Stanford, California
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California
Correspondence
Michael T. Longaker, Department of Surgery, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305. Email: [email protected]
Search for more papers by this author
Funding information Stanford University Transplant and Tissue Engineering Center of Excellence; Stanford University Child Health Research Institute; American College of Surgeons Resident Research Scholarship; Stanford University Tissue and Transplant Engineering Center of Excellence Program Fellowship; Society of University Surgeons Resident Scholar Award
Abstract
Since the discovery of scarless fetal skin wound healing, research in the field has expanded significantly with the hopes of advancing the finding to adult human patients. There are several differences between fetal and adult skin that have been exploited to facilitate scarless healing in adults including growth factors, cytokines, and extracellular matrix substitutes. However, no one therapy, pathway, or cell subtype is sufficient to support scarless wound healing in adult skin. More recently, products that contain or mimic fetal and adult uninjured dermis were introduced to the wound healing market with promising clinical outcomes. Through our review of the major experimental targets of fetal wound healing, we hope to encourage research in areas that may have a significant clinical impact. Additionally, we will investigate therapies currently in clinical use and evaluate whether they represent a legitimate advance in regenerative medicine or a vulnerary agent. WIREs Dev Biol 2018, 7:e309. doi: 10.1002/wdev.309
This article is categorized under:
- Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration
- Plant Development > Cell Growth and Differentiation
- Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells
Graphical Abstract
The discovery of fetal scarless skin wound healing is an important breakthrough whose investigation drives many aspects of regenerative medicine and stem cell research. Several features of fetal scarless wound healing are well studied, but the exact mechanism to recapitulate scarless wound healing in adult skin remains elusive (Reprinted with permission from Leavitt et al. (2016). Copyright 2016 Springer).
FURTHER READING
- Atala, A., Lanza, R., Thomson, J., & Nerem, R. (2011). Scarless wound healing. In Principles of regenerative medicine ( 2nd ed.). London: Elsevier.
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